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LPA — PI3

Text-mined interactions from Literome

Kou et al., Biochemistry 2002 : In BAEC, activation of eNOS by LPA is completely blocked by pertussis toxin, by the intracellular calcium chelator BAPTA ( 1,2-bis ( aminophenoxy ) ethane-N, N,N ', N'-tetraacetic acid ), and by the phosphoinositide 3-kinase (PI3-K) inhibitor wortmannin, but is unaffected by U0126, an inhibitor of mitogen activated protein ( MAP ) kinase pathways
Yart et al., Biochim Biophys Acta 2002 (MAP Kinase Signaling System) : Recent reports have shown that phosphoinositide 3-kinases (PI3Ks) mediate various biological activities of lysophosphatidic acid (LPA) , including cell proliferation or survival
Grey et al., Endocrinology 2002 : LPA and S1P induced PI-3 kinase dependent activation of p70 S6 kinase, but rapamycin, a specific inhibitor of p70 S6 kinase activation, did not prevent phospholipid induced osteoblast survival
Menard et al., Cell Signal 2003 : Activation of PAK1 by LPA was independent of PI3-kinase and the EGF receptor, but was inhibited by dominant negative RhoA
Takeda et al., EMBO J 1999 : The RAS independent activation of MAP kinase by LPA was blocked by inhibitors of phosphatidylinositol 3-kinase (PI3K) or by overexpression of a dominant negative mutant of the gamma isoform of PI3K