◀ Back to FAS

ESR1 — FAS

Text-mined interactions from Literome

Osipo et al., J Natl Cancer Inst 2003 (Breast Neoplasms) : Paradoxically, fulvestrant reversed this effect and stimulated MCF-7TAMLT tumor growth apparently through ERalpha mediated regulation of Fas , HER2/neu, and NF-kappaB
Menendez et al., Oncogene 2004 (Adenocarcinoma...) : We evaluated the effects of FAS inhibition on E2- and TAM induced estrogen receptor ( ER ) transcriptional activity by using transient cotransfection assays with an estrogen-response element reporter construct ( ERE-Luciferase ) ... FAS inhibition also resulted in a marked downregulation of E2-stimulated ERalpha expression, and noticeably impaired E2-induced ERalpha nuclear accumulation ... Moreover, depletion of FAS by RNAi also caused loss of ERalpha expression, downregulation of PR, and accumulation of p21WAF1/CIP1 and p27Kip1 in E2-stimulated Ishikawa cells