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IL10 — VIP

Text-mined interactions from Literome

Wang et al., Regul Pept 1999 : Previous reports indicate that VIP and the structurally related peptide PACAP, inhibit IL-2 and IL-10 production in antigen stimulated T lymphocytes ... The antagonists based on the neurotensin-VIP hybrid molecule did not affect the inhibitory effect of VIP/PACAP on IL-2 and IL-10 production, confirming that astrocytes and T lymphocytes express different receptors
Delgado et al., J Biol Chem 1999 : We showed previously that VIP and PACAP inhibit the production of macrophage derived tumor necrosis factor-alpha, interleukin (IL)-6 , nitric oxide, and IL-12
Leceta et al., Ann N Y Acad Sci 2000 (Inflammation) : VIP/PACAP inhibit the production of TNF alpha, IL-6, IL-12, and nitric oxide ( NO ), and stimulate IL-10 in peritoneal macrophages and Raw 264.7 cells ... VIP/PACAP inhibit iNOS expression through reduction in NFkB and IRF-1 binding, and augment IL-10 by increasing CREB binding
Ganea et al., Crit Rev Oral Biol Med 2002 (Shock, Septic) : In activated macrophages, VIP and PACAP inhibit the production of pro-inflammatory agents ( cytokines, chemokines, and nitric oxide ), and stimulate the production of the anti-inflammatory cytokine IL-10
Kodali et al., J Immunol 2004 (Hypersensitivity, Delayed) : VIP augmented the production of the IL-10 in LPS stimulated XS106 cells while down regulating IL-12 and IL-1beta production
Larocca et al., Int Immunopharmacol 2007 : The inhibitory effect of VIP induced IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP ... We conclude that both PGE2 and VIP inhibit nitric oxide production and increase IL-10 induced by LPS in NOD macrophages and VIP effect is mediated through an increase of COX metabolites and IL-10
Gutiérrez-Cañas et al., Brain Behav Immun 2008 (Arthritis, Rheumatoid) : VIP increases the levels of IL-10 and IL-4 in the supernatant of human CD4 ( + ) CD45RA ( + ) cells cultured in a non conditioned or a Th2 conditioned situation
Calafat et al., Neuroimmunomodulation 2007 (Disease Models, Animal...) : VIP was not effective to prevent nitrite accumulation and modestly increased IL-10 levels in macrophages coincubated with acinar cells
Fraccaroli et al., Br J Pharmacol 2009 : Also, during the trophoblast-maternal PBMCs interaction, VIP reduced pro-inflammatory mediators [interleukin (IL)-6, monocyte chemoattractant protein 1, nitric oxide ], while increasing IL-10
Temerozo et al., PloS one 2013 : VIP and PACAP up-regulated macrophage secretion of the ß-chemokines CCL3 and CCL5 and the cytokine IL-10 , whose neutralization reversed the neuropeptide induced inhibition of HIV-1 replication
Martinez et al., J Immunol 1996 : In this study, we investigated the effects of VIP and of the structurally related neuropeptide PACAP-38 on the expression of IL-10 in murine lymphocyte cultures ... The fact that VIP , PACAP-38, and forskolin, all known cAMP inducers, also inhibit IL-10 production, suggests the participation of cAMP in signal transduction
Ganea et al., Adv Neuroimmunol 1996 : In contrast, the inhibitory effect of VIP and PACAP on IL-10 production proceeds through a direct transcriptional event
Hernanz et al., J Neuroimmunol 1996 : Differential effects of gastrin releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects
Tang et al., Ann N Y Acad Sci 1996 : VIP has been previously shown to inhibit IL-2, IL-4, and IL-10 production in murine lymphocytes stimulated through the TCR associated CD3 complex
Jiang et al., Ann N Y Acad Sci 1998 : These results indicate that both subsets of peripheral T lymphocytes express VIP1 and VIP2, but not PVR1 receptors, and that the inhibitory effect of VIP/PACAP on IL-2 and IL-10 production is mediated by both VIP1 and VIP2 receptors
Delgado et al., J Immunol 1999 : Although VIP/PACAP do not induce IL-10 by themselves, they enhance IL-10 production in LPS stimulated macrophages