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GATA3 — IL10

Text-mined interactions from Literome

Shoemaker et al., J Immunol 2006 : We showed that ectopic expression of GATA-3 in naive primary CD4+ T cells enhanced expression of IL-10 by these cells and uncovered a possible mechanism for this effect ... Despite being recruited in vivo to two locations on the Il-10 locus, GATA-3 did not transactivate the IL-10 promoter
Chang et al., Eur J Immunol 2007 : In Th2 cells, expression of the cytokine IL-10 is also induced by GATA-3
Umetsu et al., J Immunol 2009 : Coexpression of Ikaros and GATA-3 further increases IL-10 production, showing that these two factors have an additive effect on activating Il10 expression
Notani et al., PLoS Biol 2010 : In the presence of Dickkopf 1 (Dkk1), an inhibitor of Wnt signalling, GATA-3 is downregulated and the expression of signature T ( H ) 2 cytokines such as IL-4, IL-10 , and IL-13 is reduced , indicating that Wnt signalling is essential for T ( H ) 2 differentiation