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LEP — TGFBR2

Text-mined interactions from Literome

Han et al., Kidney Int 2001 (Diabetes Mellitus) : Leptin stimulates type I collagen production in db/db mesangial cells : glucose uptake and TGF-beta type II receptor expression ... In db/db mesangial cells, leptin increased 2-deoxy-D-glucose ( 2DOG ) uptake dose dependently and stimulated gene expression of TGF-beta type II receptor ( TbetaRII ) and alpha1 ( I ) collagen, but not TGF-beta1
Wolf et al., Am J Kidney Dis 2002 (Body Weight...) : Conversely, in mesangial cells, leptin upregulates synthesis of the TGF-beta type II receptor , but not TGF-beta1, and stimulates glucose transport and type I collagen production through signal transduction pathways involving phosphatidylinositol-3-kinase
Tang et al., Biochem Biophys Res Commun 2003 : These effects of leptin on fibrogenesis may be mediated by TGFbeta1, since leptin increases the TGFbeta type II receptor and augments the effect of TGFbeta1 on collagen production by stellate cells