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CDK2 — MCM4
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
MCM4
—
CDK2
(direct interaction, enzymatic study)
Komamura-Kohno et al., FEBS J 2006*
-
IRef Biogrid Interaction:
MCM4
—
CDK2
(direct interaction, enzymatic study)
Ishimi et al., J Biol Chem 2000*
-
IRef Hprd Interaction:
MCM4
—
CDK2
(in vivo)
Bakema et al., J Immunol 2006*, Komamura-Kohno et al., FEBS J 2006*
-
IRef Hprd Interaction:
MCM4
—
CDK2
(in vitro)
Bakema et al., J Immunol 2006*, Komamura-Kohno et al., FEBS J 2006*
Text-mined interactions from Literome
Ishimi et al., J Biol Chem 2003
:
Based on results that showed that the DNA helicase activity of the
MCM4-6-7 complex is negatively
regulated by
CDK2 phosphorylation, we suggest that the phosphorylation of MCM4 in the checkpoint control inhibits DNA replication, which includes blockage of DNA fork progression, through inactivation of the MCM complex
Zhu et al., Cell cycle (Georgetown, Tex.) 2005
:
We show that
CDK2 suppression
results in decreased
MCM4 phosphorylation at multiple serine and threonine sites