◀ Back to IRS1

IRS1 — JAK2

Pathways - manually collected, often from reviews:

• BioCarta growth hormone signaling pathway: GH/GH R/GH R/JAK2/JAK2 complex (GHR-JAK2-GH1) → IRS-1 (IRS1) (modification, activates)
• Reactome Reaction: IRS1 → JAK2 (reaction) Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007
• Reactome Reaction: IRS1 → JAK2 (indirect_complex) Szanto et al., Proc Natl Acad Sci U S A 2000, Martín-Romero et al., Cell Immunol 2001, Duan et al., J Biol Chem 2004, Li et al., Mol Endocrinol 2007, Hill et al., J Clin Invest 2008, Buettner et al., Nat Med 2008, Bjørbaek et al., J Biol Chem 1997
• WikiPathways EPO Receptor Signaling: Complex of GRB2-RAF1-SOS1-IRS2-JAK2-IRS1-RASA1 → MAP2K1 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: IRS1 — JAK2 (direct interaction, enzymatic study) Gual et al., Endocrinology 1998*
• IRef Biogrid Interaction: IRS1 — JAK2 (physical association, affinity chromatography technology) Kawazoe et al., J Exp Med 2001*
• IRef Hprd Interaction: IRS1 — JAK2 (in vivo) Carvalheira et al., Endocrinology 2003*

Text-mined interactions from Literome

Liang et al., Endocrinology 1999 : Tyrosine phosphorylated JAK2 resulting from GH stimulation was included in the amino-terminal IRS-1 fusion precipitates ; however, neither tyrosine phosphorylation of JAK2 nor treatment of cells with GH before extraction was necessary for the specific JAK2-IRS-1 interaction to be detected
Li et al., Mol Endocrinol 2007 : JAK2 was required for leptin stimulated phosphorylation of insulin receptor substrate 1 (IRS1) , an upstream activator of the phosphatidylinositol 3-kinase pathway
Girasol et al., PloS one 2009 : Surprisingly, some of these effects are dependent on signal transduction through the IRS1/PI3-kinase , but not on the activation of JAK2
Britschgi et al., Cancer Cell 2012 (Breast Neoplasms...) : Mechanistically, PI3K/mTOR inhibition increased IRS1 dependent activation of JAK2/STAT5 and secretion of IL-8 in several cell lines and primary breast tumors
Burfoot et al., J Biol Chem 1997 : Janus kinase dependent activation of insulin receptor substrate 1 in response to interleukin-4, oncostatin M, and the interferons ... For the mutant human fibrosarcoma cell lines, phosphorylation of IRS-1 through the insulin-like growth factor receptor is independent of JAK1, JAK2 , or Tyk2
Thirone et al., Endocrinology 1999 : The correlation between JAK2 tyrosyl phosphorylation and IRS-1 tyrosyl phosphorylation in response to GH together with the results of the in vitro tyrosine kinase assay are consistent with the hypothesis that JAK2 may mediate GH-induced phosphorylation of IRS-1