◀ Back to MMP13
MMP13 — MMP14
Pathways - manually collected, often from reviews:
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Ellerbroek et al., Cancer Res 1999
(Ovarian Neoplasms) :
Aggregation of beta1 integrins with immobilized 21C8 or P4C10 antibodies stimulated
MMP dependent pro-MMP-2 activation and accumulation of a M ( r ) 43,000 form of membrane type 1 MMP
(MT1-MMP) , a cell surface activator of pro-MMP-2, in cell extracts
Majka et al., Invest Ophthalmol Vis Sci 2001
(Disease Models, Animal...) :
During the angiogenic period from P13 to P17,
MMP-2 and -9, and
MT1-MMP message expression
increased in experimental retinas compared with control samples
Ala-Aho et al., Int J Cancer 2002
(Carcinoma, Squamous Cell...) :
The enhanced invasion capacity of
MMP-13 expressing HT-1080 cells was
dependent on
MMP activity, as it was blocked by MMP inhibitor Batimastat ( BB-94 ) and tissue inhibitor of metalloproteinases-3 ( TIMP-3 )
Ruangpanit et al., Exp Cell Res 2002
:
Accumulation of collagen over time correlated with increased levels of both mature MMP-2 and cell associated membrane type 1-MMP
(MT1-MMP) , and subsequently
increased mRNA levels for
MT1-MMP , providing temporal resolution of the `` nontranscriptional '' and `` transcriptional '' effects of collagen on MT-1MMP functionality
Adair-Kirk et al., J Immunol 2003
(Inflammation) :
AQARSAASKVKVSMKF also
induced expression of
MMP-14 , while MMP-2, MMP-3, MMP-7, MMP-12, and
MMP-13 were not induced by this peptide
Munshi et al., J Biol Chem 2004
(Carcinoma, Squamous Cell...) :
Treatment of oral squamous cell carcinoma cells with TGF-beta1 promoted
MMP dependent cell scattering and collagen invasion, increased expression of MMP-2 and
MT1-MMP , and enhanced MMP-2 activation
Higashiyama et al., Hepatology 2007
(Liver Cirrhosis...) :
Whereas
MMP-13 was transiently expressed mainly in the cells clustering in the periportal areas,
MMP-9 expression and enzymatic activity were
detected over the resolution process in several different kinds of cells located in the portal areas and along the fibrous septa
Sanka et al., Invest Ophthalmol Vis Sci 2007
:
Primary human TM ( HTM ) cells treated with different actin cytoskeleton interfering agents, including cytochalasin D, latrunculin A, ethacrynic acid ( ECA ), a Rho kinase inhibitor ( Y-27632 ), and H-7 ( serine/threonine kinase inhibitor ), were examined for changes in actin cytoskeletal organization by phalloidin staining,
MMP-2 activation by gelatin zymography, expression of
MT1-MMP by quantitative real-time PCR analysis, levels of tissue inhibitor of metalloproteinases ( TIMP-1 and TIMP-2 ), and activation of p38 mitogen activated protein kinase ( p38 MAPK ) and extracellular signal regulated protein kinase ( ERK ) by immunoblotting
De Croos et al., J Orthop Res 2010
:
It also appears that
MT1-MMP does not
regulate MMP-13 gene expression, as MT1-MMP-siRNA pretreatment had no effect on MMP-13 expression following mechanical stimulation
Ito et al., Biochem Biophys Res Commun 2010
(Disease Progression...) :
In HT1080 cells, positive both in MT1-MMP and
MT2-MMP , the migration as well as the invasion was
impaired by
MT1-MMP or MT2-MMP suppression
Kim et al., Rheumatol Int 2012
(Arthritis, Rheumatoid...) :
In conclusion,
MMP-9 and uPA might be
involved in the activation of
pro-MMP-13 through unknown mechanisms in arthritic diseases
Swamydas et al., Cell Adh Migr 2013
(Mammary Neoplasms, Animal...) :
Additionally, the addition of specific
MMP9/MMP13 and MMP14 inhibitors
prevented the
MMP activities of supernatants collected from 4T1 cells incubated with D1CM, CCL5 or CCL9 ... Additionally, the addition of specific MMP9/MMP13 and
MMP14 inhibitors
prevented the
MMP activities of supernatants collected from 4T1 cells incubated with D1CM, CCL5 or CCL9