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EPHB2 — TYR
Text-mined interactions from Literome
Hermanns et al., J Biol Chem 2000
:
Moreover,
Tyr ( 861 ) is
essential for activation of
ERK1/2 and for full activation of the alpha(2)-macroglobulin promoter, but not for an exclusively STAT-responsive promoter
Cunnick et al., J Biol Chem 2001
:
We found that both
Tyr-627 and Tyr-659 of Gab1 were
required for SHP2 binding to Gab1 and for
ERK2 activation by EGF
Dorsey et al., Blood 2002
(Leukemia, Myeloid) :
Analysis of these cell lines indicated that induction of Gab2WT expression, but not
Gab2Tyr604Phe expression,
led to
Erk activation, growth arrest, cell spreading, and enlargement ; expression of megakaryocyte/platelet lineage-specific integrins alphaIIb/beta3 ( CD41/CD61 ) ; and upregulation of RNA for megakaryocyte/platelet proteins
Kim et al., J Cell Sci 2003
:
In contrast, a specific extracellular signal regulated protein kinase (
ERK ) pathway inhibitor, PD98059,
increased tyrosinase activity and melanin production, and PD98059 also restored the S1P induced reduction of tyrosinase activity and pigmentation
Fu et al., Nutr Cancer 2003
(Neoplasm Invasiveness...) :
Tyr/Phe deprivation
inhibits expression and phosphorylation of focal adhesion kinase ( FAK ) and
extracellular regulated kinase (ERK) in DU145 but not PC3 or normal cells
Arnaud et al., Biochem J 2004
(Leukemia, Prolymphocytic, T-Cell) :
Expression of the Gab2
Tyr-614 -- > Phe ( Y614F ) mutant, defective in SHP-2 association,
prevents ERK ( extracellular-signal regulated kinase ) activation and expression of a luciferase reporter plasmid driven by the c-fos SRE ( serum response element ), indicating that interaction of SHP-2 with Gab2 is required for ERK activation in response to IL-2
Huang et al., J Biol Chem 2004
:
Full activation of
ERK2 requires dual phosphorylation of Thr183 and
Tyr185 in the activation loop
Choi et al., J Dermatol Sci 2006
(Hypopigmentation) :
These results suggest that hinokitiol induced
ERK phosphorylation
reduces MITF and
TYR transcription, and mediates the action of hinokitiol on melanogenesis
Jin et al., Arch Dermatol Res 2008
:
Furthermore, ERK functionally regulated the MbetaCD induced melanin formation in melanocytes ; a
ERK inhibitor, PD98059, almost completely
attenuated the MbetaCD mediated inhibition of melanin synthesis and down-regulation of MITF and
tyrosinase expression
Son et al., J Pharm Pharmacol 2011
(Melanoma, Experimental) :
The
ERK inhibitor
increased tyrosinase activity and melanin production and reversed the acteoside induced decrease in tyrosinase activity and melanin content
Li et al., FEBS J 2013
:
With stimuli,
ERK activity is significantly
increased by the phosphorylation of Thr202 and
Tyr204 at its activation loop
Chiluiza et al., J Biol Chem 2013
(Glomerulosclerosis, Focal Segmental) :
Phosphorylation of Thr-70, Ser-282, and
Tyr-31/285 were not
necessary for
ERK activation by mutant TRPC6, although a phosphomimetic TRPC6 S282E mutant was capable of ERK activation
Kim et al., Life Sci 2013
:
Furthermore, a specific
ERK pathway inhibitor, PD98059, blocked GGA induced melanin reduction and then
prevented downregulation of MITF and
tyrosinase by GGA
Van der Zon et al., Biochemistry 1996
:
We have examined whether this specific Tyr residue contributes to the generation of TK-specific responses, such as
Tyr phosphorylation of Shc,
activation of Ras and
Erk1,2 , and stimulation of DNA synthesis