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EPHB2 — RELN
Text-mined interactions from Literome
Simó et al., Cereb Cortex 2007
(MAP Kinase Signaling System) :
Although rat sarcoma viral oncogene was weakly activated upon Reelin treatment, pharmacological inhibition of the PI3K pathway blocked
Reelin dependent
ERK activation , which indicates cross talk between the ERK and PI3K pathways ... Our findings demonstrate that
Reelin triggers
ERK signaling in an SFK/mDab1- and PI3K dependent manner and that ERK activation is required for Reelin dependent transcriptional activation and the detachment of neurons migrating from the SVZ
Bouché et al., Cell Res 2013
:
Reelin induces
EphB activation ... Here, we demonstrate that
Reelin binds to the extracellular domains of EphB transmembrane proteins,
inducing receptor clustering and activation of
EphB forward signaling in neurons, independently of the ` classical ' Reelin receptors, ApoER2 and VLDLR