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AGTR2 — EPHB2

Text-mined interactions from Literome

Lehtonen et al., Mol Endocrinol 1999 : Alanine substitutions further demonstrated that lysine 240, asparagine 242, and serine 243 are key residues for AT2 induced apoptosis, ERK inhibition, and SHP-1 activation ... To examine whether a functional link exists between activation of SHP-1 and apoptosis, we used a catalytically inactive SHP-1 mutant and demonstrated that preventing SHP-1 activation strongly attenuates AT2 induced ERK inhibition and apoptosis
Shibasaki et al., Hypertension 2001 : Maximal ERK activity induced by Ang II was increased 1.9- and 2.2-fold by AT(2) inhibition, which was abolished by orthovanadate but not okadaic acid or pertussis toxin ... Stable overexpression of SHP-1-dominant negative mutant completely abolished AT(2) mediated inhibition of EGFR and ERK activation ... These findings suggested that AT(2) inhibits ERK activity by inducing SHP-1 activity, leading to decreases in AP-1 activity and AP-1 regulated gene expression, in which EGFR dephosphorylation plays an important role via association of SHP-1
Takahashi et al., Eur J Clin Invest 2004 (Cardiomegaly...) : These data suggest that PKC and ERK1/2 are activated by an angiotensin II receptor mediated pathway and might play an important role in the progression of cardiac hypertrophy in renal failure
Ahn et al., J Biol Chem 2004 : Differential kinetic and spatial patterns of beta-arrestin and G protein mediated ERK activation by the angiotensin II receptor
Chow et al., Prostate 2008 (Prostatic Neoplasms) : Functional AT(2)-receptors together with Ang II were identified in both cell lines and stimulation of these receptors inhibited EGF induced DNA synthesis and ERK2 phosphorylation
Yamada et al., Life Sci 1998 : Moreover we observed that AT1 receptor stimulation activated extracellular signal regulated kinase ( ERK ), whereas the AT2 receptor stimulation inhibited the activation of ERK