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SOD2 — TP53
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Hussain et al., Cancer Res 2004
:
Microarray expression analysis of doxorubicin exposed, related human lymphoblasts, p53 wild-type ( WT ) Tk6, and p53 mutant WTK1 identified the
p53 dependent up-regulation of manganese
superoxide dismutase ( MnSOD ) and glutathione peroxidase 1 (GPx)
Doonan et al., J Neurochem 2009
:
Furthermore, inhibition of
p53 partially
blocks the observed increase in
SOD-2 and sestrin-1 expression indicating that p53 expression is upstream of both antioxidants
Dhar et al., J Biol Chem 2010
:
Nuclear factor kappaB- and specificity protein 1-dependent
p53 mediated bi-directional regulation of the human manganese
superoxide dismutase gene
Shen et al., Sci China C Life Sci 2003
:
In addition,
SOD/catalase down-regulated the expression of
p53 , p21/wafl/cipl and TBARS but up-regulated bcl-2 and increased indirectly the level of NO, NO2-/NO3-, and inhibited DNA fragmentation