Garnovskaya et al., Biochemistry 2003
:
5-HT and Ang II rapidly activated NHE-1 via their G protein coupled receptors ( 5-HT(2A) and AT(1) ) as assessed by proton microphysiometry of quiescent cells and by measurements of intracellular pH on a FLIPR ( fluorometric imaging plate reader )
Mukhin et al., J Biol Chem 2004
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EGF receptor blockade attenuated ERK activation, but not NHE-1 activation by 5-HT and Ang II , suggesting that the EGF receptor and NHE-1 work in parallel to stimulate ERK activity in RASM cells, converging distal to the EGF receptor but at or above the level of Ras in the Ras-MEK-ERK pathway
Thieme et al., Am J Physiol Cell Physiol 2008
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Losartan ( 10 ( -7 ) M ) and dimethyl-BAPTA-AM ( 10 ( -7 ) M ) decreased significantly the stimulatory effect of ANG II ( 10 ( -9 ) M ) and induced an increase in Na(+)/H(+) exchanger 1 ( NHE-1 ) activity with ANG II ( 10 ( -6 ) M )
Liu et al., J Pharmacol Sci 2013
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Moreover, Ang II increased NHE-1 phosphorylation