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PIK3R1 — SYT1
Text-mined interactions from Literome
Rajala et al., J Virol 2005
:
We demonstrate phosphorylation of GSK-3beta and nuclear translocation of the
p65 subunit of NF-kappaB, both downstream targets of the PI3K/Akt pathway, in adenovirus infected corneal fibroblasts in a
PI3K dependent manner
Huang et al., J Immunol 2007
:
However, both JAK inhibitor I and
PI3K inhibitor
had no effect on the DNA binding activities of
p65 and p50 to NF-kappaB consensus sequences
Zhao et al., Biochem Pharmacol 2008
:
In addition, the pharmacological inhibitors of
PI3K ( wortmannin and LY294002 )
enhance phosphorylation of NF-kappaB
p65 on Ser529 and Ser536 residues, which result in enhanced p65 transactivation activity
Jin et al., Stroke 2011
(Infarction, Middle Cerebral Artery...) :
PI3K? deficiency
suppressed ischemia/reperfusion induced nuclear factor-?B
p65 ( Ser536 ) phosphorylation and the expression of the pro-oxidant enzyme NADPH oxidase ( Nox1, Nox2, and Nox4 ) and proinflammatory adhesion molecules ( E- and P-selectin, intercellular adhesion molecule-1 ) at different time points