Gene interactions and pathways from curated databases and text-mining

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IL12B — JAK2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Sudarshan et al., J Immunol 1999 : We examined this and found that TGF-beta1 did not have any effect on IL-12 induced phosphorylation of JAK2 , TYK2, and STAT4 although TGF-beta1 inhibited IL-2- and IL-12 induced IFN-gamma production
Bright et al., J Immunol 1999 (Encephalomyelitis, Autoimmune, Experimental) : Tyrphostin B42 inhibits IL-12 induced tyrosine phosphorylation and activation of Janus kinase-2 and prevents experimental allergic encephalomyelitis ... Treatment of activated T cells with tyrphostin B42 inhibited the IL-12 induced tyrosine phosphorylation and activation of Jak-2 without affecting Tyk-2 kinase
Franchimont et al., J Immunol 2000 : This occurred even though the level of expression of IL-12 receptors and IL-12 induced Janus kinase phosphorylation remained unaltered
Natarajan et al., J Immunol 2002 (Demyelinating Diseases...) : In vitro treatment of activated T cells with curcumin inhibited IL-12 induced tyrosine phosphorylation of Janus kinase 2 , tyrosine kinase 2, and STAT3 and STAT4 transcription factors
Sugimoto et al., Eur J Immunol 2003 : IL-12 activates TYK2 and Janus kinase (JAK)-2 to induce the phosphorylation of various signal transducers and activators of transcription ( STAT ) proteins
Muthian et al., J Clin Immunol 2004 (Disease Models, Animal...) : In vitro treatment of activated T cells with quercetin blocks IL-12 induced tyrosine phosphorylation of JAK2 , TYK2, STAT3, and STAT4, resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation
Yu et al., J Immunol 2005 : Interestingly, IL-12 induced activation of Jak2 and STAT4, critical components for IL-12 mediated cellular responses, was shortened or attenuated in mutant T cells
Walker et al., Arch Virol Suppl 2005 (Ehrlichiosis) : Ehrlichiae attach to L-selectin and E-selectin, inhibit phagolysosomal fusion, apoptosis, and JAK/STAT activation, and downregulate IL-12 , IL-15, IL-18, TLR2 and 3, and CD14
Muthian et al., J Neurosci Res 2006 (Disease Models, Animal...) : Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the IL-12 induced tyrosine phosphorylation of JAK2 , TYK2, STAT3, and STAT4 in association with a decrease in T cell proliferation in vitro
Shaw et al., J Immunol 2006 (Genetic Predisposition to Disease...) : The Jak , Tyk2, is activated in response to IL-12 and IFN-alphabeta and promotes IFN-gamma production by Th1-type CD4 cells
Yu et al., Biochem Pharmacol 2008 : Like quercetin inhibits macrophage induced cytokine production, it also blocks IL-12 dependent JAK-STAT signaling in Th cells
Wang et al., Blood 2008 (MAP Kinase Signaling System) : IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was mediated by Janus kinase-signal transducers and activators of transcription ( JAK-STAT ) -dependent signaling without induction of calcium flux
Paradowska-Gorycka et al., Scand J Immunol 2010 (Arthritis, Rheumatoid...) : IL-23 binding to an IL-23 receptor expressed on dendritic cells, macrophages and monocytes triggers the activation of Jak2 and Tyk2, which in turn phosphorylates STAT1, STAT3, STAT4 and STAT5 as well as induce formation of STAT3-STAT4 heterodimers
Conzelmann et al., Biochem Pharmacol 2010 : JAK2 mediated enhancing effects on IL-12p70 but did not inhibit IL-10 release, whereas Tyk2 mediated inhibitory effects on IL-12p70 release in this system ... The mechanism by which complementary IFN-?/JAK activities affect IL-12p70 production involves STAT1 activation and de novo induction of interferon-responsive factors (IRF)-1 and IRF-8
Bacon et al., J Exp Med 1995 : Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2 : differential use of Janus family tyrosine kinases by IL-2 and IL-12 ... IL-12 , but not IL-2, stimulates the tyrosine phosphorylation of TYK2 and JAK2 , whereas JAK1 and JAK3, which are phosphorylated in response to IL-2, are not phosphorylated after IL-12 treatment
Yu et al., J Immunol 1996 : Finally, IL-2 induced tyrosine phosphorylation of JAK1 and JAK3, while IL-12 induced phosphorylation of JAK2 and TYK2 in both preactivated primary NK and NK3.3 cells
Gollob et al., Eur J Immunol 1997 : One feature of Th2 differentiation in mice is the loss of IL-12 induced Jak2 and Stat4 activation, which is accompanied by the inability to produce IFN-gamma in response to IL-12
Bright et al., J Immunol 1998 : TGF-beta inhibits IL-12 induced activation of Jak-STAT pathway in T lymphocytes
Ahn et al., J Immunol 1998 : 2D6 ( IL-12 ) and 2D6 ( IL-2 ) similarly proliferating in response to IL-12 induced comparable levels of JAK2 activation and STAT5 phosphorylation