◀ Back to IL12B
IL12B — JAK2
Pathways - manually collected, often from reviews:
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
→
STAT4
(modification, activates)
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BioCarta no2-dependent il-12 pathway in nk cells:
IL-12/IL-12R complex (IL12RB1-IL12RB2-IL12B_IL12A)
→
JAK2
(modification, activates)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12 (IL12B/IL12A)
→
IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12 (IL12B/IL12A)
→
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
(modification, collaborate)
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BioCarta il12 and stat4 dependent signaling pathway in th1 development:
IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-TYK2-JAK2)
→
IL-12/IL-12R/TYK2/JAK2 complex (IL12RB1-IL12RB2-IL12B_IL12A-TYK2-JAK2)
(modification, collaborate)
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NCI Pathway Database IL12-mediated signaling events:
STAT4 (STAT4)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Chin et al., Nature 2002, Bacon et al., Proc Natl Acad Sci U S A 1995, Jacobson et al., J Exp Med 1995, Naeger et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, other species
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NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
RIP2 (RIPK2)
(modification, activates)
Chin et al., Nature 2002, Bacon et al., Proc Natl Acad Sci U S A 1995, Jacobson et al., J Exp Med 1995, Naeger et al., J Biol Chem 1999
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
PI3K complex (PIK3CA-PIK3R1)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, activates)
Parham et al., J Immunol 2002, Cho et al., J Immunol 2006
Evidence: mutant phenotype, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
Granzyme A (GZMA)
(transcription, activates)
Salcedo et al., J Immunol 1993
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT3 (dimer)-active complex (STAT3)
(modification, activates)
Jacobson et al., J Exp Med 1995, Zou et al., J Biol Chem 1997
Evidence: assay, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT1 (STAT1)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL23-mediated signaling events:
SOCS3 (SOCS3)
→
IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
SOCS3 (SOCS3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23/IL23R/JAK2/TYK2/SOCS3 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2-SOCS3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Chen et al., Proc Natl Acad Sci U S A 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
mTOR (MTOR)
(modification, activates)
Kusaba et al., J Biol Chem 2005
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
LCK (LCK)
(modification, activates)
Pignata et al., Cell Immunol 1995
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT1 (dimer) complex (STAT1)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT6 (STAT6)
(modification, activates)
Moriggl et al., J Immunol 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
MIP1B (CCL4)
(transcription, activates)
Galon et al., J Immunol 1999
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Rodriguez-Galán et al., J Immunol 2005
Evidence: assay, other species
-
NCI Pathway Database IL27-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL27/IL27R/JAK2/TYK2 complex (IL27RA-JAK2-IL6ST-TYK2-IL27-EBI3)
(transcription, activates)
Chen et al., Nature 2000, Yoshida et al., Immunity 2001, Pflanz et al., Immunity 2002, Kamiya et al., J Immunol 2004
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL2 (IL2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, activates)
Parham et al., J Immunol 2002
-
NCI Pathway Database IL23-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, activates)
Parham et al., J Immunol 2002
-
NCI Pathway Database IL12-mediated signaling events:
STAT4 (STAT4)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
→
STAT4 (dimer) complex (STAT4)
(modification, activates)
Yoshimoto et al., J Immunol 2003
Evidence: reporter gene
-
NCI Pathway Database IL23-mediated signaling events:
STAT4 (STAT4)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
STAT3 (STAT3)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002
Evidence: assay, physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
STAT4 (STAT4)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL1 beta (IL1B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Yamamoto et al., Biochem Biophys Res Commun 1999, Bacon et al., J Exp Med 1995, Hunter et al., J Immunol 1995, Presky et al., Proc Natl Acad Sci U S A 1996, Zou et al., J Biol Chem 1997, Gollob et al., Blood 1998
Evidence: mutant phenotype, assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
TCR/CD3/MHC I/CD8 complex (CD247-CD3E-CD3G-CD3D-HLA-A-B2M-CD8A-CD8B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Takemoto et al., J Immunol 2006
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23 complex (IL23A-IL12B)
→
IL23R/JAK2 complex (IL23R-JAK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23 complex (IL23A-IL12B)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL23-mediated signaling events:
IL23R/JAK2 complex (IL23R-JAK2)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Oppmann et al., Immunity 2000, Parham et al., J Immunol 2002, Zou et al., J Biol Chem 1997
Evidence: physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT3 (STAT3)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
p38 alpha (MAPK14)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
SPHK2 (SPHK2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
SPHK2 (SPHK2)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12/IL12R/TYK2/JAK2/SPHK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SPHK2)
(modification, collaborate)
Yoshimoto et al., J Immunol 2003
Evidence: assay, physical interaction, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT5A (STAT5A)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IFN-gamma (IFNG)
(modification, activates)
Gollob et al., Blood 1998
Evidence: assay
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Schindler et al., J Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, activates)
Yang et al., Nat Immunol 2001
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
STAT1 (STAT1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
p38 alpha (MAPK14)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL2/IL2R complex (IL2RA-IL2RB-IL2RG-IL2)
(modification, activates)
Gollob et al., J Immunol 1999
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
Calcineurin A alpha-beta B1 ()
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(transcription, inhibits)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
TCR/CD3/MHC II/CD4 complex (CD247-CD3E-CD3G-CD3D-HLA-DRA-HLA-DRB1-CD4)
(transcription, activates)
Wittmann et al., J Leukoc Biol 2006
Evidence: mutant phenotype, assay
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12 complex (IL12A-IL12B)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12Rbeta1/TYK2 complex (IL12RB1-TYK2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
NOS2 (NOS2)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, activates)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL12Rbeta2/JAK2 complex (IL12RB2-JAK2)
(modification, collaborate)
Diefenbach et al., Science 1999, Presky et al., Proc Natl Acad Sci U S A 1996
Evidence: mutant phenotype, assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
NF kappa B2 p52/RelB complex (NFKB2-RELB)
(translocation, activates)
Grohmann et al., Immunity 1998
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
HLX1 (HLX)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
STAT4 (dimer) complex (STAT4)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
→
IL18/IL18R complex (IL18-IL18R1-IL18RAP)
(modification, activates)
Becknell et al., Blood 2007
Evidence: assay, other species
-
NCI Pathway Database IL12-mediated signaling events:
SOCS1 (SOCS1)
→
IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
SOCS1 (SOCS1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL12-mediated signaling events:
IL12/IL12R/TYK2/JAK2/SOCS1 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2-SOCS1)
→
IL12/IL12R/TYK2/JAK2 complex (IL12A-IL12B-IL12RB1-IL12RB2-TYK2-JAK2)
(modification, collaborate)
Endo et al., Nature 1997
Evidence: physical interaction
-
NCI Pathway Database IL23-mediated signaling events:
IFN-gamma (IFNG)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(transcription, inhibits)
Langrish et al., J Exp Med 2005, Harrington et al., Nat Immunol 2005
Evidence: mutant phenotype, other species
-
NCI Pathway Database IL23-mediated signaling events:
STAT5A (STAT5A)
→
IL23/IL23R/JAK2/TYK2 complex (IL23A-IL12B-IL23R-IL12RB1-JAK2-TYK2)
(modification, collaborate)
Parham et al., J Immunol 2002
Evidence: physical interaction
Text-mined interactions from Literome
Sudarshan et al., J Immunol 1999
:
We examined this and found that TGF-beta1 did not have any effect on
IL-12 induced phosphorylation of
JAK2 , TYK2, and STAT4 although TGF-beta1 inhibited IL-2- and IL-12 induced IFN-gamma production
Bright et al., J Immunol 1999
(Encephalomyelitis, Autoimmune, Experimental) :
Tyrphostin B42 inhibits
IL-12 induced tyrosine phosphorylation and activation of
Janus kinase-2 and prevents experimental allergic encephalomyelitis ... Treatment of activated T cells with tyrphostin B42 inhibited the
IL-12 induced tyrosine phosphorylation and activation of
Jak-2 without affecting Tyk-2 kinase
Franchimont et al., J Immunol 2000
:
This occurred even though the level of expression of IL-12 receptors and
IL-12 induced
Janus kinase phosphorylation remained unaltered
Natarajan et al., J Immunol 2002
(Demyelinating Diseases...) :
In vitro treatment of activated T cells with curcumin inhibited
IL-12 induced tyrosine phosphorylation of
Janus kinase 2 , tyrosine kinase 2, and STAT3 and STAT4 transcription factors
Sugimoto et al., Eur J Immunol 2003
:
IL-12 activates TYK2 and
Janus kinase (JAK)-2 to induce the phosphorylation of various signal transducers and activators of transcription ( STAT ) proteins
Muthian et al., J Clin Immunol 2004
(Disease Models, Animal...) :
In vitro treatment of activated T cells with quercetin blocks
IL-12 induced tyrosine phosphorylation of
JAK2 , TYK2, STAT3, and STAT4, resulting in a decrease in IL-12 induced T cell proliferation and Th1 differentiation
Yu et al., J Immunol 2005
:
Interestingly,
IL-12 induced
activation of
Jak2 and STAT4, critical components for IL-12 mediated cellular responses, was shortened or attenuated in mutant T cells
Walker et al., Arch Virol Suppl 2005
(Ehrlichiosis) :
Ehrlichiae attach to L-selectin and E-selectin,
inhibit phagolysosomal fusion, apoptosis, and
JAK/STAT activation, and downregulate
IL-12 , IL-15, IL-18, TLR2 and 3, and CD14
Muthian et al., J Neurosci Res 2006
(Disease Models, Animal...) :
Treatment of activated T cells with 1,25 ( OH ) 2D3 also inhibited the
IL-12 induced tyrosine phosphorylation of
JAK2 , TYK2, STAT3, and STAT4 in association with a decrease in T cell proliferation in vitro
Shaw et al., J Immunol 2006
(Genetic Predisposition to Disease...) :
The
Jak , Tyk2, is activated in
response to
IL-12 and IFN-alphabeta and promotes IFN-gamma production by Th1-type CD4 cells
Yu et al., Biochem Pharmacol 2008
:
Like quercetin inhibits macrophage induced cytokine production, it also blocks
IL-12 dependent
JAK-STAT signaling in Th cells
Wang et al., Blood 2008
(MAP Kinase Signaling System) :
IL-12 and IL-18 stimulated autoreactively activated NKT cells to secrete IFN-gamma, and this was
mediated by Janus kinase-signal transducers and activators of transcription (
JAK-STAT ) -dependent signaling without induction of calcium flux
Paradowska-Gorycka et al., Scand J Immunol 2010
(Arthritis, Rheumatoid...) :
IL-23 binding to an IL-23 receptor expressed on dendritic cells, macrophages and monocytes
triggers the activation of
Jak2 and Tyk2, which in turn phosphorylates STAT1, STAT3, STAT4 and STAT5 as well as induce formation of STAT3-STAT4 heterodimers
Conzelmann et al., Biochem Pharmacol 2010
:
JAK2 mediated enhancing effects on
IL-12p70 but did not inhibit IL-10 release, whereas Tyk2 mediated inhibitory effects on IL-12p70 release in this system ... The mechanism by which complementary
IFN-?/JAK activities
affect IL-12p70 production involves STAT1 activation and de novo induction of interferon-responsive factors (IRF)-1 and IRF-8
Bacon et al., J Exp Med 1995
:
Interleukin 12 (IL-12) induces tyrosine phosphorylation of
JAK2 and TYK2 : differential use of Janus family tyrosine kinases by IL-2 and IL-12 ...
IL-12 , but not IL-2,
stimulates the tyrosine phosphorylation of TYK2 and
JAK2 , whereas JAK1 and JAK3, which are phosphorylated in response to IL-2, are not phosphorylated after IL-12 treatment
Yu et al., J Immunol 1996
:
Finally, IL-2 induced tyrosine phosphorylation of JAK1 and JAK3, while
IL-12 induced phosphorylation of
JAK2 and TYK2 in both preactivated primary NK and NK3.3 cells
Gollob et al., Eur J Immunol 1997
:
One feature of Th2 differentiation in mice is the loss of
IL-12 induced
Jak2 and Stat4 activation, which is accompanied by the inability to produce IFN-gamma in response to IL-12
Bright et al., J Immunol 1998
:
TGF-beta inhibits
IL-12 induced activation of
Jak-STAT pathway in T lymphocytes
Ahn et al., J Immunol 1998
:
2D6 ( IL-12 ) and 2D6 ( IL-2 ) similarly proliferating in response to
IL-12 induced comparable levels of
JAK2 activation and STAT5 phosphorylation