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CREB5 — STAR

Text-mined interactions from Literome

Manna et al., Mol Endocrinol 2002 : Transient expression of wild- type CREB in MA-10 mouse Leydig tumor cells further increased the levels of ( Bu ) 2cAMP induced progesterone synthesis, StAR promoter activity, StAR mRNA, and StAR protein
Manna et al., J Mol Endocrinol 2003 : Studies on the effects of the functional integrity of the CRE half-sites on CREB dependent ( Bu ) ( 2 ) cAMP mediated StAR gene transcription demonstrated the greater importance of the CRE2 site in comparison with the CRE1 and CRE3 sites ... Specific mutations that eliminated the binding sites of CRE and SF-1 elements, either alone or in combination, resulted in an attenuation of StAR promoter activity, indicating that CREB and SF-1 can regulate StAR gene transcription in a cooperative fashion
Manna et al., Mol Endocrinol 2006 : Conversely, StAR gene transcription was markedly inhibited by expression of nonphosphorylatable CREB ( Ser ( 133 ) Ala ), dominant negative A-CREB, and dominant negative c-Jun ( TAM-67 ) mutants
Manna et al., Endocrinology 2009 (Granulosa Cell Tumor...) : Ectopic expression of CREB binding protein enhanced CREB mediated transcription of the StAR gene, an event that was markedly repressed by the adenovirus E1A oncoprotein