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IFNG — PSME1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Früh et al., Curr Opin Immunol 1999
:
IFN-gamma upregulates gene expression of several proteasomal subunits as well as the proteasome regulator
PA28 ; this implicated their role in antigen degradation
McCusker et al., Immunogenetics 1999
:
Two proteasome activators
PA28alpha and beta, which have been implicated in antigen processing for loading class I MHC molecules, are synthesized in
response to
Ifn-gamma
van Hall T et al., J Exp Med 2000
:
Interferon (IFN)-gamma induces expression of three catalytically active proteasome subunits ( LMP2, LMP7, and MECL-1 ) and the proteasome associated activator
PA28
Fabunmi et al., J Cell Sci 2001
:
Interferon gamma regulates accumulation of the proteasome activator
PA28 and immunoproteasomes at nuclear PML bodies
Groettrup et al., Crit Rev Immunol 2001
(Virus Diseases) :
Proteasome activity is further changed by the
IFN-gamma mediated induction of the proteasome regulator
PA28alpha/beta and the downregulation of PA28gamma
Krüger et al., Rev Physiol Biochem Pharmacol 2003
:
In addition,
interferon-gamma also
induces the synthesis of the proteasome activator
PA28 which, as part of the so-called hybrid proteasome, exerts a more selective function in antigen presentation
Kloetzel et al., Nat Immunol 2004
:
Proteasome dependent epitope processing is greatly improved through the
interferon-gamma induced formation of immunoproteasomes and the activator complex
PA28
Kloetzel et al., Biochim Biophys Acta 2004
:
Interferon-gamma induces the formation of immunoproteasomes and the synthesis of the proteasome activator
PA28
Piccinini et al., Anticancer Res 2005
(Central Nervous System Neoplasms...) :
By
IFN-gamma and TNFalpha stimulus, these subunits are replaced by their counterparts LMP2, MECL-1 and LMP7, defined inducible subunits, thus originating the immunoproteasome, and expression of the proteasome activator
PA28 is
enhanced
Stratford et al., FEBS Lett 2006
:
In contrast, levels of the 11S proteasome regulator, PA28, were increased by
IFN-gamma even in senescent cells, and both immunosubunits and
PA28 increased with the reversible growth arrest in confluent cell cultures