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CCK — TAC1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Mosher et al., Peptides 1996
:
Because CCK-8 has affinity for both CCKA and CCKB receptor subtypes, we wanted to determine the subtype involved in
CCK-8 induced
TAC ...
CCK-8 induced
TAC , although the highest dose of L-365,260 ... These partial antagonistic effects of L-365,260 on
CCK-8 induced
TAC were replicated in our second study ... In our third study, we observed that another CCKB antagonist, the dipeptoid CI-988, also partially antagonized
CCK-8 induced
TAC at a dose of 0.1, but not 1.0 or 10.0, mumol/kg
Mosher et al., Peptides 1998
:
Because CCK-4 failed to induce TAC,
CCK-8 apparently
induced TAC via all three routes by an action at a CCK ( a ), not CCK ( B ), receptor mechanism ... We demonstrate that
CCK-8 can
induce mild
TAC at either peripheral or central sites and suggest that these effects of CCK-8 may be independent and may be a sign of salience but not necessarily of toxicosis