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RELA — TNFAIP3
Pathways - manually collected, often from reviews:
-
BioCarta cd40l signaling pathway:
NF-kappa-B/I-kappa-B-alpha complex (NFKBIA-RELA)
→
TNFAIP3
(protein ubiquitination, collaborate)
-
BioCarta cd40l signaling pathway:
TNFAIP3
→
I-kappa-B-alpha/RELA/p50/ubiquitin complex (NFKBIA-RELA)
(protein ubiquitination, inhibits)
Text-mined interactions from Literome
Vendrell et al., Oncogene 2007
(Breast Neoplasms) :
The
zinc-finger protein A20/TNFAIP3 , an
inhibitor of
nuclear factor-kappaB (NF-kappaB) activation, has been shown to protect MCF-7 breast carcinoma cells from TNFalpha induced apoptosis
Schmitz et al., J Exp Med 2009
(Chromosome Deletion...) :
NF-kappaB activation through various stimuli is negatively
regulated by the
zinc finger protein A20 ... This report identifies
TNFAIP3 ( A20 ), a key
regulator of
NF-kappaB activity, as a novel tumor suppressor gene in cHL and PMBL
Song et al., Proc Natl Acad Sci U S A 1996
:
The tumor necrosis factor-inducible
zinc finger protein A20 interacts with TRAF1/TRAF2 and
inhibits NF-kappaB activation
Heyninck et al., FEBS Lett 1999
:
The cytokine-inducible
zinc finger protein A20 inhibits IL-1 induced
NF-kappaB activation at the level of TRAF6