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Ivison et al., J Immunol 2007
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Third, pharmacologic inhibition of PKC or PKD with Gö6976 resulted in reduced expression and secretion of IL-8 and prevented the flagellin induced activation of p38 MAPK , but treatment with the PKC inhibitor Gö6983 had no significant effects on these phenotypes
Tan et al., Arterioscler Thromb Vasc Biol 2009
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Using multiple approaches, including dominant negative mutants and small interfering RNA knock-down, we found that lysoPC induced PKD2 activation was required for the activation of both ERK and p38 MAPK Steiner et al., Cell Immunol 2010
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PKD1 and PKD2 inhibition reduced NF-kappaB activity but not MAPK activation