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CES2 — TP53

Text-mined interactions from Literome

Wierdl et al., J Pharmacol Exp Ther 2003 : p53 mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10- [ 4- ( 1-piperidino ) -1-piperidino ] carbonyloxycamptothecin ( CPT-11 )
Choi et al., Cancer Biol Ther 2006 (Adenocarcinoma...) : We examined whether p53 activated by the DNA damaging drug 5-fluorouracil ( 5-FU ) also induces CES-2 expression ... These results taken together show that activated p53 directly regulates CES-2 expression via a p53 binding site, representing a novel mechanism through which the p53 pathway modulates drug metabolism