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IGF2 — SP1

Text-mined interactions from Literome

Kang-Park et al., Biochem Biophys Res Commun 2001 (Carcinoma, Hepatocellular...) : We have recently shown that HBx protein, one of the causative agents of hepatocellular carcinomas, regulates Sp1 mediated transcription of insulin-like growth factor II promoter 4 ( Lee et al. ( 1998 ) Oncogene 16, 2367-2380 ) ... These results demonstrate that PKC and p44/p42 MAPK cascades are the essential signaling pathways in Sp1 mediated IGF-II gene activation by HBx
Maor et al., J Endocrinol 2006 (Breast Neoplasms) : In summary, our studies demonstrate that IGF-IR gene transcription in breast cancer cells is controlled by interactions between ERalpha and Sp1
Yuen et al., Oncogene 2007 (Carcinoma, Renal Cell...) : In Sp1-null Drosophila Schneider cells, IGF1R promoter activity was dependent on exogenous Sp1 , and was suppressed by full-length VHL protein ( pVHL ) but only partially by truncated VHL lacking the Sp1 binding motif
Lee et al., Oncogene 1998 (Carcinoma, Hepatocellular) : The human hepatitis B virus transactivator X gene product regulates Sp1 mediated transcription of an insulin-like growth factor II promoter 4 ... These results indicate that HBV-X functions as a positive regulator of transcription, and that Sp1 is a direct target for the transcriptional regulation of IGF-II