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EPHB2 — SCNN1A

Text-mined interactions from Literome

Wang et al., J Biol Chem 2000 : Consistent with our hypothesis, exogenous H ( 2 ) O ( 2 ) -mediated repression of alpha-ENaC GRE activity is partially blocked by either a specific inhibitor for extracellular signal regulated kinase ( ERK ) pathway activation, U0126, or dominant negative ERK, suggesting that, in part, activated ERK may mediate the repressive effects of H ( 2 ) O ( 2 ) on alpha-ENaC expression ... Taken together, we hypothesize that oxidative stress impairs Na ( + ) transport activity by inhibiting dexamethasone dependent alpha-ENaC GRE activation via both ERK dependent and thioredoxin-sensitive pathways
Zentner et al., J Biol Chem 2001 : Together, our results demonstrate that Ras/ERK mediated induction of HMGI-C is required to effectively repress GR/Dex stimulated transcription of alpha-ENaC gene and STAT3 mediated transactivation
Frank et al., J Biol Chem 2003 : The inhibitory effect of TGF-beta1 on sodium uptake and alphaENaC expression in ATII cells was mediated by activation of the MAPK, ERK1/2 ... This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2 dependent inhibition of the alphaENaC promoter activity