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EPHB2 — RAC3

Text-mined interactions from Literome

Nosaka et al., Biochem Biophys Res Commun 2001 (Fibrosarcoma) : Rac is activated by tumor necrosis factor alpha and is involved in activation of Erk
Woo et al., J Biol Chem 2002 : Consistent with those findings, leukotriene B ( 4 ) Rac-dependently stimulates ERK and cytosolic phospholipase A ( 2 ) activity, and transient transfection with plasmid expressing Rac ( V12 ), a constitutively activated Rac1 mutant, also dose-dependently stimulates ERK activity
Arai et al., Oncogene 2002 : A dominant negative Rac mutant, Rac17N, also inhibited the cytokine induced activation of Erk as well as Elk-1
Woo et al., Mol Cells 2002 (MAP Kinase Signaling System) : Our results showed that LPS induced the activation of ERK and p38 MAP kinase in a Rac dependent manner, suggesting a mediatory role of Rac1 in LPS signaling to MAPKs stimulation
Eblen et al., Mol Cell Biol 2002 (MAP Kinase Signaling System) : Phosphorylation of ERK2-delta19-25 but not of wild-type ERK2 in response to Ras V12 was greatly inhibited by dominant negative Rac ... Activated forms of Rac and Cdc42 could enhance the association of wild-type ERK2 with MEK1 but not with MEK2 in serum starved adherent cells
Zhong et al., Blood 2003 (MAP Kinase Signaling System) : Rac and Cdc42, but not Ras or Rho, were responsible for this MAPK/ERK activation ... We conclude from these data that Rac/Cdc42 dependent activation of MAPK/ERK is a critical event in the immediate phagocytic response of PMNs to microbial challenge
Hammarberg et al., Biochem Pharmacol 2004 : In addition, inhibition of Rac/Cdc42 , small GTPases of the Rho family, by clostridium toxin B, diminished p38 phosphorylation but did not affect ERK1/2
Eblen et al., Mol Cell Biol 2004 (MAP Kinase Signaling System) : It was previously shown that Rac-p21 activated kinase (PAK) signaling regulated the physical association of MEK1 with ERK2 through phosphorylation sites in the proline-rich sequence (PRS) of MEK1
Nishida et al., J Biol Chem 2005 : Dominant negative Rac inhibited angiotensin II-stimulated ROS production, JNK activation, and p38 MAPK activation but did not affect ERK activation
Bruinsma et al., Proc Natl Acad Sci U S A 2007 (MAP Kinase Signaling System) : Chimaerin and Rac regulate cell number, adherens junctions, and ERK MAP kinase signaling in the Drosophila eye
Notcovich et al., Exp Cell Res 2010 : On the other hand, H1R induced ERK1/2 activation was inhibited by U73122 but not affected by C3 or beta2-chimaerin, suggesting that ERK1/2 activation was dependent on PLC and independent of RhoA or Rac
Gest et al., BMC cancer 2013 (Breast Neoplasms...) : Secondly, we investigated the effects of Rac3 inhibition on the expression and activation of related signaling molecules, including NF-?B and ERK
Frost et al., Mol Cell Biol 1996 : Although neither activated Rac nor the PAKs stimulate ERK2 activity, overexpression of either dominant negative Rac2 or the N-terminal regulatory domain of PAK1 inhibits Ras mediated activation of ERK2, suggesting a permissive role for Rac in the control of the ERK pathway
Miranti et al., Curr Biol 1998 : This pathway may regulate multiple downstream events in hematopoietic cells, including Rac induced lamellipodia formation, tyrosine phosphorylation of Cbl, and activation of JNK, ERK2 and the phosphatidylinositol 3'-kinase regulated kinase Akt