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CD40 — TP53
Text-mined interactions from Literome
Teoh et al., Blood 2000
(Multiple Myeloma) :
Using p21-luciferase reporter assays, we confirmed that
CD40 induces
p53 transactivation in RPMI 8226 and HS Sultan cells cultured under permissive, but not restrictive, conditions ... Furthermore,
CD40 activation of these MM cells under permissive, but not restrictive, temperatures
increased the expression of
p53 and p21 mRNA and protein
Liao et al., Zhonghua Zhong Liu Za Zhi 2001
(Nasopharyngeal Neoplasms) :
Induction of
p53 expression could be
blocked by phosphorothiate analogs of antisense oligonucleotides to NF-kappa B p65 and LMP1, but not by NF-kappa
B p50
Wang et al., Int J Biochem Cell Biol 2013
:
In conclusion, through down regulation of p53 expression, Survivin attenuates the suppressing
effect of
p53 on
NF-?B ( p50 ) expression and then enhances BCRP expression