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IGF1R — IRS2

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: IRS2 → IGF1R (directlyIncreases, IRS2 Activity)
  Evidence: from http://www.ub.rug.nl/eldoc/dis/medicine/n.wilczak/c1.pdf The intrinsic tyrosine kinase activity of the IGF-I receptor is enhanced and phosphorylates multiple substrates, including IRS1 and IRS2 on tyrosine residues
• OpenBEL Selventa BEL large corpus: IRS2 → IGF1R (directlyIncreases, IRS2 Activity)
  Evidence: At least nine intracellular substrates of the insulin/IGF-I receptor kinases have been identified (Fig. 2). Four of these belong to the family of insulin-receptor substrate (IRS) proteins9. Other substrates include Gab-1, p60dok, Cbl, APS and isoforms of Shc10.
• NCI Pathway Database IGF1 pathway: IRS2/Crk complex (IRS2-CRK) → IGF-1R heterotetramer/IGF1/IRS1 complex (IGF1R-IGF1-IRS1) (modification, collaborate)
  Beitner-Johnson et al., J Biol Chem 1996
  Evidence: mutant phenotype, assay
• Reactome Reaction: IGF1R → IRS2 (reaction) Karas et al., Endocrinology 2001, Schreyer et al., Endocrinology 2003, Kim et al., Oncogene 2004, Rakatzi et al., Arch Physiol Biochem 2006, Cuevas et al., J Hepatol 2007, Siemeister et al., J Biol Chem 1995, Xu et al., J Biol Chem 1995, He et al., J Biol Chem 1996*, Takahashi et al., Endocrinology 1997, Fantin et al., J Biol Chem 1998, Kim et al., Endocrinology 1998, Kim et al., J Biol Chem 1998
• Reactome Reaction: IGF1R → IRS2 (indirect_complex) Karas et al., Endocrinology 2001, Schreyer et al., Endocrinology 2003, Kim et al., Oncogene 2004, Rakatzi et al., Arch Physiol Biochem 2006, Cuevas et al., J Hepatol 2007, Siemeister et al., J Biol Chem 1995, Xu et al., J Biol Chem 1995, He et al., J Biol Chem 1996*, Takahashi et al., Endocrinology 1997, Fantin et al., J Biol Chem 1998, Kim et al., Endocrinology 1998, Kim et al., J Biol Chem 1998
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: FGFR2/KDR/INSR/FGFR3/IGF1R/KIT/FGFR1/EPHA2/EGFR/CSF1R/FGFR4/FLT1/FLT4/NGFR/MET/PDGFRA/PDGFRB/TEK → IRS1/IRS4/IRS2 (activation)
• WikiPathways Insulin Signaling: IGF1R → SHC3/IRS1/IRS2/SHC1/IRS4/SHC2/GAB1 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind_translation Interaction: IGF1R — IRS2 (two hybrid) Sawka-Verhelle et al., J Biol Chem 1996*
• IRef Intact Interaction: IGF1R — IRS2 (physical association, two hybrid) He et al., J Biol Chem 1996*
• IRef Ophid Interaction: IGF1R — IRS2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Cui et al., Oncogene 2003 (Breast Neoplasms) : We found that insulin receptor substrate-2 (IRS-2) levels were markedly induced by progesterone and the synthetic progestin R5020 in MCF-7 and other progesterone receptor (PR) positive breast cancer cell lines, whereas IRS-1 and the IGF-I receptor were not induced
Kwon et al., Cancer Res 2009 (Adenocarcinoma...) : Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta
Xuan et al., J Biol Chem 2010 (Diabetes Mellitus...) : To examine genetically the involvement of Irs1 and Irs2 in Igf1r signaling, we generated double mutant mice lacking Igf1r specifically in pancreatic ß cells in an Irs1- or Irs2-null background
Sun et al., Endocrinology 2011 : No alterations were observed in downstream signaling targets of prolactin and progesterone, suggesting that activation of the IGF-1R may directly regulate expression of IRS-1/2 during alveolar development and differentiation