Gene interactions and pathways from curated databases and text-mining

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EPHB2 — RASA1

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Ye et al., Eur J Biochem 2000 (Choriocarcinoma...) : Taken together, it is concluded that okadaic acid induces the expression of p100 RasGAP protein in JEG-3 cells preceded by activation of ERK and AP-1 cascade, and that this okadaic acid induced p100 RasGAP expression is independent of protein kinase C-mediated pathway but requires c-Jun/AP-1 function
Elowe et al., Mol Cell Biol 2001 (MAP Kinase Signaling System) : Inactivation of Ras, induced by ephrin B1 stimulation of NG108 neuronal cells, requires EphB2 tyrosine kinase activity and is blocked by a truncated form of p120-Ras GTPase activating protein ( p120-RasGAP ), suggesting that EphB2 signals through the SH2 domain protein p120-RasGAP to inhibit the Ras-MAPK pathway
Lin et al., Cell Microbiol 2003 (MAP Kinase Signaling System) : Both tyrosine phosphatase activity and GAP activity were responsible for SptP inhibition of Raf ( Y340D ) -induced ERK activation, but only GAP activity was responsible for inhibition of the membrane localized forms of Raf-1
Zhang et al., Am J Pathol 2006 (Carcinoma, Squamous Cell...) : The results demonstrate that expression of rap1GAP in oropharyngeal SCC down-regulated active rap1, ERK activation, and proliferation
Leander et al., PLoS Comput Biol 2012 (Tularemia) : The model confirms that phagocytosis associated changes in the composition of the cell membrane can inhibit ERK activity and predicts that Akt and Ras-GAP synergize to inhibit ERK