◀ Back to CASP6
CASP6 — NLRP7
Text-mined interactions from Literome
Khare et al., Immunity 2012
(Bacterial Infections) :
Activation of
NLRP7 promoted ASC dependent
caspase-1 activation, IL-1ß and IL-18 maturation, and restriction of intracellular bacterial replication, but not caspase-1 independent secretion of the proinflammatory cytokines IL-6 and tumor necrosis factor-a
Hedl et al., Am J Physiol Gastrointest Liver Physiol 2013
(Crohn Disease...) :
Importantly, we find that, during chronic Nod2 stimulation,
NLRP3/NLRP1 inflammasome
mediated caspase-1 activation with subsequent IL-1 secretion is essential for the subsequent bifurcation to downregulated proinflammatory cytokines and upregulated bacterial killing