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IL2 — TGFB1

Pathways - manually collected, often from reviews:

• NCI Pathway Database IL12 signaling mediated by STAT4: IL2 (IL2) → TGFB1 (TGFB1) (transcription, activates) Cai et al., J Immunol 2000*, Schindler et al., J Immunol 2001, Szabo et al., Science 2002, Morinobu et al., Proc Natl Acad Sci U S A 2002, Kobayashi et al., J Exp Med 1989*, Hunter et al., Eur J Immunol 1995*, Kaplan et al., Nature 1996
  Evidence: mutant phenotype, assay, other species

Text-mined interactions from Literome

Sudarshan et al., J Immunol 1999 : We examined this and found that TGF-beta1 did not have any effect on IL-12 induced phosphorylation of JAK2, TYK2, and STAT4 although TGF-beta1 inhibited IL-2- and IL-12 induced IFN-gamma production
McKarns et al., Immunopharmacology 2000 : TGF-beta 1 differentially regulates IL-2 expression and [ 3H ] -thymidine incorporation in CD3 epsilon mAb- and CD28 mAb activated splenocytes and thymocytes ... Toward this end, we have quantified the concentration- and time dependent effect of TGF-beta(1) on interleukin-2 (IL-2) protein secretion as an index of T lymphocyte activation and [ 3H ] -thymidine incorporation as an index of cell proliferation in primary splenocytes and thymocytes ... Our results suggest that TGF-beta(1) stimulates IL-2 production at low concentrations ( 0.1-1 pg/ml ) and conversely inhibits IL-2 production at high concentrations ( 1-10 ng/ml ) in CD3epsilon monoclonal antibody ( mAb ) +/-CD28 mAb activated splenocytes
Loomis et al., Am J Physiol Cell Physiol 2001 (Inflammation...) : IL-4, IL-10, TGF-beta(1) , and PGE ( 2 ) suppressed IL-2 production with IC ( 50 ) of 500, 1, 36,000, and 0.01 pg/ml, respectively
Zhao et al., Cancer Immunol Immunother 2002 (Liver Neoplasms, Experimental) : We have previously reported that transforming growth factor beta ( TGF-beta ) produced by rat hepatoma cell line KDH-8 cells suppressed the interleukin-2 (IL-2) production of T cells and the tumoricidal activity of macrophages in KDH-8 tumor bearing rats and that the inhibition of TGF-beta production by low-dose bleomycin restored these activities significantly
Riemekasten et al., Arthritis Rheum 2003 : Interferon-gamma (IFNgamma), interleukin-2 (IL-2), IL-4, transforming growth factor beta , and IL-10 production increased in response to the peptide in young mice ; only IFNgamma and IL-2 were increased in older, diseased mice
Sung et al., Int Immunopharmacol 2003 : Even though IL-2 levels were strongly suppressed by TGF-beta1 to trace levels, antibody neutralization studies showed that IL-2 is still a basic requirement for the proliferation of anti-CD3/anti-CD28/TGF-beta1 stimulated naïve T cells
Bry et al., Am J Obstet Gynecol 1992 (Obstetric Labor, Premature) : Human amnion cells in monolayer culture were treated with interleukin-1 , tumor necrosis factor, or vehicle in the presence or absence of transforming growth factor-beta
Brooks et al., Immunology 1992 : Recombinant human interleukin-4 (IL-4) and transforming growth factor-beta ( TGF-beta ) reduce recombinant interleukin-2 (IL-2) induction of lymphokine activated killer ( LAK ) cell activity from human peripheral blood mononuclear cells ( PBMC )
Gunnlaugsdottir et al., Int Immunol 2005 (Necrosis) : TGFbeta1 significantly reduced the secretion of IL-2 and IFNgamma, but such suppression was partially prevented by anti-CD28 induced co-stimulation
Méndez-Dávila et al., J Endocrinol Invest 2004 (Osteoporosis) : We investigated the effects of 17betaestradiol and two selective estrogen receptor modulators, tamoxifen and raloxifene, on the expression and release of constitutive and interleukin-1 stimulated interleukin (IL)-6, transforming growth factor-beta1 ( TGF-beta1 ) and insulin-like growth factor-1 by osteoblasts in primary culture from trabecular bone of healthy post-menopausal women
Layh-Schmitt et al., Curr Opin Rheumatol 2008 (Spondylarthropathies) : In mice, transforming growth factor-beta and interleukin-6 are critical, whereas interleukin-23 is more important at later stages promoting interleukin-17 production
Chakraborty et al., Clin Immunol Immunopathol 1991 : The suppression of high-affinity IL-2R induction on T cells did not result from tumor necrosis factor-alpha and beta or from transforming growth factor-beta as these cytokines were not detected in the cell-free supernatant from the MJ TIL culture
Espevik et al., Cell Immunol 1990 : The effect of recombinant ( r ) interleukin-1 beta ( rIL-1 beta ) and transforming growth factor-beta ( TGF-beta ) on the production of interleukin-2 (IL-2) and interleukin-6 (IL-6) from an antigen-specific ( LBRM-33-1A5 ) and an antigen-nonspecific ( EL-4-NOB-1 ) T-cell line was investigated
Ruegemer et al., J Immunol 1990 : Regulatory effects of transforming growth factor-beta on IL-2- and IL-4 dependent T cell-cycle progression
Ye et al., J Leukoc Biol 1995 : Furthermore, both transforming growth factor-beta and genistein, a tyrosine kinase inhibitor, could suppress IL-2 and IL-12 signaling but CsA was generally inactive
Reinhold et al., Cytokine 1994 : In this study we have analysed in parallel the effects of TGF-beta 1 on both DNA synthesis and production of the cytokines IL-1, IL-2 , IL-6, and TNF-alpha by pokeweed mitogen stimulated peripheral blood mononuclear cells ... With this stimulation system we show that TGF-beta 1 at a concentration of 15 ng/ml significantly suppresses IL-2 and IL-6 production
Nelson et al., J Leukoc Biol 1994 : IL-2 induced resident peritoneal macrophages to secrete > 5000 pg/ml TGF-beta 1 , a quantity that is > 500-fold higher than constitutive background levels ( 20-40 pg/ml ) and is sufficient to block intracellular killing activities
Cardillo et al., Eur J Immunol 1993 (Autoimmune Diseases...) : This suppression could not be reverted by exogenous interleukin (IL)-2 and was not directly dependent on the presence of IL-4, IL-10 or transforming growth factor-beta
Dupuy d'Angeac et al., J Cell Physiol 1993 : Since EL 4-6.1 cells share phenotypic and functional characteristics with the immature thymic subset lacking CD4 and CD8 accessory molecules ( DN ), we investigated the effect of TGF-beta 1 on the IL-2R 55kD alpha chain expression and proliferation of activated DN cells and especially in DN cells that do not express CD3 ... We thus also tested the effect of TGF-beta 1 on IL-2R alpha chain expression in these in vitro differentiating CD3-DN cells ... We found that TGF-beta 1 neither significantly affected IL-2R expression nor changed CD4 or CD8 expression ... Hence, in CD3-DN cells, the effect of TGF-beta 1 on IL-2R expression seems to be restricted to proliferating cells
Xu et al., Kidney Int 1995 : Our investigation demonstrated that : ( a ) intragraft expression of IL-10 mRNA and IL-2 mRNA are significant correlates of acute rejection ; ( b ) IL-4, IL-7, IFN-gamma and TGF-beta 1 mRNA expression do not correlate with acute rejection ; and ( c ) IL-10 does not prevent in vivo expression of IFN-gamma, IL-2 , IL-7, or TGF-beta 1
Fischer et al., Ann Oncol 1995 (Carcinoma, Non-Small-Cell Lung...) : Furthermore, TGF beta 1 suppressed secretion of IL-2 , IFN alpha, IFN gamma, TNF alpha but not of IL-1 alpha and IL-1 beta in whole blood cell cultures from healthy individuals
Ayoub et al., Immunol Invest 1996 : In the presence of exogenous IL-2 , TGF-beta 1 was found to augment the proliferative response of BLTC through up-regulation of IL-2R expression, allow progression of normal cell cycle, and significantly prevent apoptosis
Kumar et al., J Cell Physiol 1996 : Induction of interleukin-1 and interleukin-8 mRNAs and proteins by TGF beta 1 in rat lung alveolar epithelial cells
Marth et al., Eur J Immunol 1997 : Regulation of transforming growth factor-beta production by interleukin-12
Fulton et al., J Infect Dis 1998 : Regulation of interleukin-12 by interleukin-10, transforming growth factor-beta , tumor necrosis factor-alpha, and interferon-gamma in human monocytes infected with Mycobacterium tuberculosis H37Ra
Han et al., J Pharmacol Exp Ther 1998 : Transforming growth factor-beta 1 ( TGF-beta1 ) promotes IL-2 mRNA expression through the up-regulation of NF-kappaB, AP-1 and NF-AT in EL4 cells ... In the present studies, we determined that TGF-beta1 induced IL-2 mRNA expression in the murine T-cell line EL4, in the absence of other stimuli ... IL-2 mRNA expression was significantly induced by TGF-beta1 ( 0.1-1 ng/ml ) over a relatively narrow concentration range, which led to the induction of IL-2 secretion