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HGF — MMP1

Text-mined interactions from Literome

Hamasuna et al., Int J Cancer 1999 (Brain Neoplasms...) : MT1 -MMP , a cell-surface activator of proMMP-2, was also up-regulated by HGF/SF in a dose dependent manner
Hanzawa et al., Carcinogenesis 2000 (Carcinoma, Squamous Cell...) : Here we examined the effect of HGF on E1AF and MMP gene expression in terms of the invasive potential of the oral squamous cell carcinoma cell line HSC3
Wang et al., Biochem Biophys Res Commun 2000 (MAP Kinase Signaling System) : Hepatocyte growth factor enhances MMP activity in human endothelial cells
Taniyama et al., Circulation 2000 (Cardiomyopathies...) : In human fibroblasts, HGF significantly increased the production of matrix metalloprotease-1 (MMP-1) and urokinase plasminogen activator, whereas HGF also significantly attenuated the reduction of MMP-1 activity induced by Ang II
Harvey et al., Br J Cancer 2000 (Mesothelioma...) : HGF/SF stimulated the expression of MMP-1 , 9 and MT1-MMP and had a slight effect on expression of the MMP inhibitor TIMP-1 but not TIMP-2
Imafuku et al., Clin Chim Acta 2002 : We also found a definite effects on copper, angiotensin converting enzyme (ACE), matrix metalloproteinase (MMP)-1 , -3 and -9, tissue inhibitor of matrix metalloproteinase ( TIMP ) -1, hepatocyte growth factor (HGF) , monoamine oxidase ( MAO ), vitamin B ( 12 ), ACTH and IL-6, though the mechanisms were not clear
Hirata et al., Biol Reprod 2003 : Membrane type-1 MMP mRNA expression in the stromal cells was augmented by tumor necrosis factor alpha (TNFalpha), IL-6, HGF , and 12-O-tetradecanoylphorbol 13-acetate
Tomita et al., Circulation 2003 : Here, we demonstrated that HGF stimulated the expression of MMP-1 , VEGF, HGF itself, and c-met in human endothelial cells and vascular smooth muscle cells
Fujiuchi et al., Oncol Rep 2003 (Neoplasm Invasiveness...) : Furthermore, HGF also increased the production of MMP-1 and -9, MT1-MMP , u-PA and uPAR of these cells
Jinnin et al., J Invest Dermatol 2005 (Scleroderma, Systemic) : Effects of hepatocyte growth factor on the expression of type I collagen and matrix metalloproteinase-1 in normal and scleroderma dermal fibroblasts ... On the other hand, matrix metalloproteinase-1 expression or activity was increased by HGF in both cells, but HGF had stronger effects in scleroderma fibroblasts than normal fibroblasts
Jinnin et al., Nucleic Acids Res 2005 (MAP Kinase Signaling System) : Matrix metalloproteinase-1 up-regulation by hepatocyte growth factor in human dermal fibroblasts via ERK signaling pathway involves Ets1 and Fli1 ... In this study, we clarified the molecular mechanism ( s ) underlying the regulation of matrix metalloproteinase (MMP)-1 gene by hepatocyte growth factor (HGF) in cultured human dermal fibroblasts
Li et al., World J Gastroenterol 2005 (Colorectal Neoplasms...) : Compared with controls, MMP-2 and MMP-9 mRNA expressions were up-regulated by HGF ( 0.997+/-0.011 vs 1.207+/-0.003, t = 35.002,P = 0.001 < 0.01 ; 0.387+/-0.128 vs 0.971+/-0.147, t = 106.036, P = 0.0000 < 0.01, respectively ) ; compared with controls, TIMP-1, TIMP-2 mRNA expressions were increased by PD98059 ( 1.344+/-0.007 vs 1.905+/-0.049, t = 17.541, P = 0.003 < 0.01 ; 1.286+/-0.020 vs 1.887+/-0.022,t = 24.623, P = 0.002 < 0.01, respectively )
Sundelin et al., Acta Otolaryngol 2005 (Carcinoma, Squamous Cell...) : The objective of this study was to investigate the effects of IL-6, soluble IL-6 receptor ( sIL-6R ), HGF , TNF-a and IL-8 on MMP-1 , -2 and -9 expression by two oral squamous cell carcinoma cell lines ( UT-SCC-20A and -24A )
Naveau et al., J Periodontol 2006 : After labeling with these maghemite nanoparticles, HGF increased secretion of IL-1beta at D1, probably inducing the increase of MMP-1 , -2, and -3 and TIMP-2
Ide et al., Int J Cancer 2006 (Neoplasm Invasiveness...) : Conversely, the elevated cancer invasion, MMP activity and c-Met phosphorylation of PK8 cells were reduced by the removal of HGF from hypoxic conditioned medium
Sherriff-Tadano et al., Mod Rheumatol 2006 (Scleroderma, Diffuse...) : Hepatocyte growth factor enhanced MMP-1 production and mRNA levels of MMP-1 and Ets-1 ( a transcriptional factor of MMPs ) ... Addition of anti-HGF antibody neutralized these effects of HGF on MMP-1 and collagen synthesis
Bogatkevich et al., Arthritis Rheum 2007 (MAP Kinase Signaling System...) : In lung fibroblasts from white SSc patients, HGF activated MAPK ( ERK-1/2 ) signaling pathways and MMP-1 , while it inhibited NF-kappaB and significantly down-regulated CTGF and collagen in a time- and dose dependent manner
Lee et al., J Korean Med Sci 2011 (Keloid) : Hepatocyte growth factor (HGF) increases the expression of matrix metalloproteinase (MMP)-1 and suppresses collagen synthesis to modulate extracellular matrix turnover
Aparicio et al., C R Seances Soc Biol Fil 1998 (Colonic Neoplasms...) : After 24 or 48 h of culture in medium supplemented with HGF, transforming growth factor-alpha ( TGF-alpha ) or sodium butyrate, MMP production by DHD/K12 cells was stimulated by HGF and TGF-alpha and inhibited by sodium butyrate