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GSK3B — MYC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MYC → GSK3B (decreases, GSK3B Activity, MYC Activity)
  Evidence: AKTactivates cell proliferation by inactivating p27 (Fujita et al., 2002) and inhibiting glycogen synthase kinase 3 (GSK3)- mediated Myc and cyclin D1 inhibition (Vivanco and Sawyers, 2002).
• OpenBEL Selventa BEL large corpus: MYC → GSK3B (decreases, MYC Activity) Rottmann et al., Proc Natl Acad Sci U S A 2005*
  Evidence: mall inhibitory RNA-induced silencing of GSK3beta prevents phosphorylation of MYC on T58, thereby inhibiting recognition of MYC by the E3 ubiquitin ligase component FBW7.
• OpenBEL Selventa BEL large corpus: MYC → GSK3B (directlyIncreases, MYC Activity)
  Evidence: 11018017;14563837;15150404;17081983
• NCI Pathway Database C-MYC pathway: Axin1/GSK3beta/PIN1/PP2A-B56alpha complex (AXIN1-GSK3B-PIN1-PPP2CA-PPP2R5A) → MYC/Max complex (MYC-MAX) (modification, activates) Sears et al., Genes Dev 2000, Gregory et al., J Biol Chem 2003, Yeh et al., Nat Cell Biol 2004, Arnold et al., Mol Cell Biol 2006, Arnold et al., EMBO J 2009
  Evidence: mutant phenotype, assay, physical interaction
• WikiPathways ErbB Signaling Pathway: GSK3B → MYC/CCND1 (inhibition)
• WikiPathways Regulation of Apoptosis by Parathyroid Hormone-related Protein: GSK3B/GSK3A → MYC (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: GSK3B — MYC (physical association, affinity chromatography technology) Gregory et al., J Biol Chem 2003
• IRef Biogrid Interaction: GSK3B — MYC (physical association, affinity chromatography technology) Arnold et al., EMBO J 2009
• IRef Dip Interaction: MYC — GSK3B (physical association, Split renilla luciferase complementation) Fan-Minogue et al., Proc Natl Acad Sci U S A 2010*
• IRef Intact Interaction: Complex of 13 proteins (association, anti tag coimmunoprecipitation) Arnold et al., EMBO J 2009
• IRef Intact Interaction: Complex of MYC-GSK3B-AXIN1-PPP2CA (association, anti tag coimmunoprecipitation) Arnold et al., EMBO J 2009

Text-mined interactions from Literome

Rottmann et al., Proc Natl Acad Sci U S A 2005 (Neoplasms) : Small inhibitory RNA induced silencing of GSK3beta prevents phosphorylation of MYC on T58, thereby inhibiting recognition of MYC by the E3 ubiquitin ligase component FBW7 ... Attenuating the GSK3beta-FBW7 axis results in stabilization of MYC , up-regulation of surface levels of the TNF related apoptosis inducing ligand death receptor 5, and potentiation of death receptor 5-induced apoptosis in vitro and in vivo
Bubman et al., Oncogene 2007 (Lymphoma, Non-Hodgkin) : Conversely, when LANA is eliminated from PEL cells using RNA interference, GSK-3beta mediated c-Myc T58 phosphorylation is restored
Chang et al., Oncogene 2008 (Prostatic Neoplasms) : C-Myc may also be regulated at the protein level by extracellular signal regulated kinase 1/2 and GSK3beta
Zhang et al., Cell cycle (Georgetown, Tex.) 2009 : Moreover, our data indicated that downregulation of c-Myc and cell cycle arrest of G ( 1 ) phase were caused not by formation of G-quadruplex structures but by activation of GSK-3beta followed by degradation of beta-catenin