Gene interactions and pathways from curated databases and text-mining

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RELA — TP53

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Webster et al., Mol Cell Biol 1999 : Moreover, endogenous, tumor necrosis factor alpha activated NF-kappaB will inhibit endogenous wild-type p53 transactivation
Kirch et al., Oncogene 1999 : Expression of human p53 requires synergistic activation of transcription from the p53 promoter by AP-1, NF-kappaB and Myc/Max
Park et al., Nephron 1999 : Decrease in NF-kappaB activity and activation of p53 induced by inhibition of interaction with ECM play roles in anoikis in SV-40 transformed collecting duct cells
Nakai et al., J Neurochem 2000 : The present results provide additional support for the view that NF-kappaB activation contributes to c-Myc and p53 induction and subsequent apoptosis in an excitotoxic model of Huntington 's disease
Shao et al., Oncogene 2000 (Adenocarcinoma...) : Overexpression of the wild-type p53 gene inhibits NF-kappaB activity and synergizes with aspirin to induce apoptosis in human colon cancer cells ... In this study, to better understand the mechanism responsible for the p53 mediated apoptosis, the effect of wild-type p53 ( wt-p53 ) gene transfer on nuclear expression of NF-kappaB was determined in human colon cancer cell lines ... A Western blot analysis of nuclear extracts demonstrated that NF-kappaB protein levels in the nuclei were suppressed by the transient expression of the wt-p53 in a dose dependent manner
Haddad et al., Biochem Biophys Res Commun 2000 : Sulfasalazine, a potent and specific inhibitor of NF-kappaB , induced Bax at the expense of Bcl-2, in a p53 dependent manner
Ryan et al., Nature 2000 : Here we show that induction of p53 causes an activation of NF-kappaB that correlates with the ability of p53 to induce apoptosis ... Activation of NF-kappaB by p53 was distinct from that mediated by tumour-necrosis factor-alpha and involved MEK1 and the activation of pp90rsk ... Inhibition of MEK1 blocked activation of NF-kappaB by p53 and completely abrogated p53 induced cell death
Ikeda et al., Biochem Biophys Res Commun 2000 : However, we found that the inhibition by RelA of p53 transcriptional activity is not completely restored by CBP/p300 overexpression and that a p53 mutant can not suppress RelA activity despite of its ability to bind CBP/p300
Ros et al., Hepatology 2001 (Carcinoma, Hepatocellular...) : Because p53 is up-regulated by TNF-alpha in an NF-kappaB dependent manner and the Mdr1b promoter contains a p53 binding site, we used liver cells expressing a dominant negative p53 to show that TNF-alpha up-regulation of Mdr1b is independent of functional p53
Zhang et al., J Biol Chem 2001 : Inhibition of cell cycle progression by the novel cyclophilin ligand sanglifehrin A is mediated through the NFkappa B-dependent activation of p53
Liao et al., Zhonghua Zhong Liu Za Zhi 2001 (Nasopharyngeal Neoplasms) : Induction of p53 expression could be blocked by phosphorothiate analogs of antisense oligonucleotides to NF-kappa B p65 and LMP1, but not by NF-kappa B p50
Tergaonkar et al., Cancer Cell 2002 : IKK2 mediated effects required its kinase function and were abrogated by coexpression of the dominant negative IkappaBalphaM, implying a role for NFkappaB in blocking chemotherapy induced p53 and cell death
de Erausquin et al., Mol Pharmacol 2003 : Treatment of mesencephalic cultures with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ( AMPA ) resulted in a number of changes that occurred selectively in dopaminergic neurons, including persistent elevation in intracellular Ca ( 2+ ) monitored with Fura-2, and a significant increase in intramitochondrial oxidation of dihydrorhodamine 123, probably associated with transient increase of mitochondrial permeability, cytochrome c release, nuclear translocation of NF kappa B , and transcriptional activation of the oncogene p53
Shimada et al., Carcinogenesis 2003 (Prostatic Neoplasms) : Inhibition of p38 or NFkappaB resulted in suppression of p53 induction and apoptosis
Rocha et al., Mol Cell Biol 2003 : p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1
Lagunoff et al., Int Rev Immunol 2003 : Virally encoded genes inhibit the activation of caspase-8 by the TNF receptor and Fas ; activate NF-kappaB to increase expression of antiapoptotic genes ; inhibit interferon response ; bind to p53 , thereby blocking p53 dependent apoptosis ; and interact with other pro- and antiapoptotic cellular genes
Culmsee et al., J Neurosci 2003 (Brain Ischemia) : In cultured neurons DNA damaging compounds induced activation of p53 , whereas NF-kappaB activity declined significantly
Guo et al., Mol Cell Biol 2004 : We found that ( i ) p19(Arf) or p53 deficiency led to a significant increase in PI 3-kinase activity, which in turn upregulated RhoA and Rac1 activities ; ( ii ) deletion of p19Arf or p53 led to an increase in cell growth rate that was in part dependent on RhoA, Rac1, and Cdc42 activities ; ( iii ) p19(Arf) or p53 deficiency caused an enhancement of the growth related transcription factor NF-kappa B and cyclin D1 activities that are partly dependent on RhoA or Cdc42 but not on Rac1 ; ( iv ) forced expression of the activating mutants of Rac1, RhoA, or Cdc42 caused a hyperproliferative phenotype of the p19Arf ( -/- ) and p53 ( -/- ) cells and promoted transformation of both cells ; ( v ) RhoA appeared to contribute to p53 regulated cell proliferation by modulating cell cycle machinery, while hyperactivation of RhoA further suppressed a p53 independent apoptotic signal ; and ( vi ) multiple pathways regulated by RhoA, including that of Rho-kinase, were required for RhoA to fully promote the transformation of p53 ( -/- ) cells
Aleyasin et al., J Neurosci 2004 : NF-kappaB inhibition also reduced p53 transcripts and p53 activity as measured by the p53-inducible messages, Puma and Noxa, implicating the p53 tumor suppressor in the mechanism of NF-kappaB mediated neuronal death ... Importantly, p53 expression still induces death in the presence of NF-kappaB inhibition, indicating that p53 acts downstream of NF-kappaB
Bohuslav et al., J Biol Chem 2004 : p53 induces NF-kappaB activation by an IkappaB kinase independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1 ... Here we describe the novel molecular mechanism through which p53 and DNA damaging agents activate NF-kappaB ... NF-kappaB induction by p53 does not occur through classical activation of the IkappaB kinases and degradation of IkappaBalpha
Fujioka et al., J Biol Chem 2004 : Consequently, NF-kappaB dependent p53 activity induced the expression of p53 regulated genes PUMA and p21 ( waf1 ) as well as apoptosis ... Importantly, lack of RelA, IKK, and p53 as well as expression of a dominant negative IkappaBalpha ( IkappaBalphaM ) inhibited NF-kappaB dependent p53 activation and apoptosis
Nasr et al., Oncogene 2005 (Leukemia-Lymphoma, Adult T-Cell...) : PS-341 treatment of these cells stabilized IkappaBalpha, IkappaBbeta, IkappaBvarepsilon, p21, p27 and p53 proteins and selectively inhibited Rel-A DNA binding NF-kappaB complexes
Jeong et al., J Biol Chem 2005 : A novel NF-kappaB pathway involving IKKbeta and p65/RelA Ser-536 phosphorylation results in p53 Inhibition in the absence of NF-kappaB transcriptional activity
Hidaka et al., J Exp Clin Cancer Res 2005 (Neoplasms) : To analyze whether p53 status mediates IL-8 expression, the effect of wild-type p53 ( wt-p53 ) gene transfer on activation of NF-kappaB was determined in both cell lines ... In contrast, luciferase reporter studies indicated that transcriptional activity of NF-kappaB is suppressed by transfection of wt-p53 ... These results show that wt-p53 gene transfer inhibits IL-8 production and NF-kappaB transcription activity in cancer cells and suggest that constitutive IL-8 production in cancer cells is associated with mutation of p53
Jeong et al., Oncogene 2005 (Cell Transformation, Viral) : Activated AKT regulates NF-kappaB activation, p53 inhibition and cell survival in HTLV-1 transformed cells ... Blocking AKT with the PI3K/AKT inhibitor LY294002 or AKT SiRNA prevented NF-kappaB activation and inhibition of p53 ... We suggest that AKT plays a role in the activation of prosurvival pathways in HTLV-1 transformed cells, possibly through NF-kappaB activation and inhibition of p53 transcription activity
El Eter et al., Can J Physiol Pharmacol 2005 (Reperfusion Injury) : Moreover, PDTC pretreatment abolished p53 expression and inhibited NF-kappaB translocation ... These results clearly demonstrate that NF-kappaB activation and pro-apoptotic protein p53 induction are involved in gastric I/R injury
Scian et al., Mol Cell Biol 2005 (Disease Progression) : Tumor derived p53 mutants induce NF-kappaB2 gene expression
Gurova et al., Proc Natl Acad Sci U S A 2005 (Carcinoma, Renal Cell) : Induction of p53 by these compounds does not involve genotoxic stress and is mediated by suppression of NF-kappaB activity ... The results demonstrate, in principle, the possibility to kill cancer cells selectively through simultaneous inhibition of NF-kappaB and activation of p53 by a single small molecule and suggest anticancer applications for the well known antimalaria drug quinacrine
Ko et al., FEBS Lett 2006 : These data suggest that NF-kappaB-dependency of the PAF induced increase in VEGF expression is due to decreased p53 activity, which is reciprocally regulated by increased NF-kappaB activity
Kikuchi et al., Oncogene 2006 : Ectopic expression of NF-kappaB decreased a half-life of p73alpha by increasing its ubiquitination levels, and thereby inhibiting the transcriptional activity as well as proapoptotic function of p73alpha, whereas NF-kappaB had undetectable effects on p53
Armstrong et al., Neoplasia (New York, N.Y.) 2006 (Brain Neoplasms...) : Moreover, p53 is necessary for NF-kappaB activation because cells with inactive p53 were resistant to NF-kappaB mediated cell death
Minsavage et al., J Pharmacol Exp Ther 2007 : Thus, disruption of p53/p90RSK mediated NF-kappaB signaling and activation of ARE/EpRE pathways may be effective strategies to delineate mechanisms of action of BFA induced inflammation and cell death signaling in immortalized versus normal skin systems
Armstrong et al., Neoplasia (New York, N.Y.) 2006 (Neuroblastoma) : Moreover, p53 is necessary for NF-kappaB activation because cells with inactive p53 were resistant to NF-kappaB mediated cell death
Weisz et al., Cancer Res 2007 (Breast Neoplasms...) : We now report that cancer associated mutant p53 can augment the induction of nuclear factor kappaB (NFkappaB) transcriptional activity in response to the cytokine tumor necrosis factor alpha (TNFalpha) ... Analysis of human head and neck tumors and lung tumors reveals a close correlation between the presence of abundant mutant p53 proteins and the constitutive activation of NFkappaB
Liang et al., Brain Res 2007 (Nerve Degeneration...) : Blockade of NF-kappaB nuclear translocation with recombinant cell-permeable peptide NF-kappaB SN50 inhibited NF-kappaB nuclear translocation and p53 induction
Plesnila et al., Cell Death Differ 2007 (Brain Injuries...) : Delayed neuronal death after brain trauma involves p53 dependent inhibition of NF-kappaB transcriptional activity ... Inhibition of p53 activity resulted in the concomitant increase in NF-kappaB transcriptional activity and upregulation of NF-kappaB-target proteins, for example X-chromosomal linked inhibitor of apoptosis ( XIAP )
Pekar et al., Reproduction 2007 (Abnormalities, Multiple...) : p53 regulates cyclophosphamide teratogenesis by controlling caspases 3, 8, 9 activation and NF-kappaB DNA binding
Guzman et al., Blood 2007 (Leukemia, Myeloid, Acute) : Molecular studies indicate the prevalent activities of DMAPT include induction of oxidative stress responses, inhibition of NF-kappaB , and activation of p53
Mi et al., Mol Ther 2008 (Carcinoma, Non-Small-Cell Lung...) : This Dox induced NF-kappaB activation and subsequent chemoresistance is dependent on expression of p53
Lee et al., Int J Cancer 2008 (Carcinoma, Squamous Cell...) : Greater modulation among HNSCC lines expressing low wt p53 than those over expressing mt p53 protein suggested that decreased p53 expression might enhance activation of NF-kappaB , STAT3 and BCL-XL
Logunov et al., Oncogene 2008 (Cell Transformation, Neoplastic...) : Cells incubated with media conditioned with different species of mycoplasma showed constitutive activation of NF-kappaB and reduced activation of p53 , common characteristics of the majority of human tumor cells, with M. arginini having the strongest effect among the species tested
Kawauchi et al., Biochem Biophys Res Commun 2008 : Activated p53 induces NF-kappaB DNA binding but suppresses its transcriptional activation ... Thus, activated p53 may suppress transcriptional activity of NF-kappaB through inhibition of IKK and histone H3 kinase on DNA, suggesting a novel p53 mediated suppression system for tumorigenesis
Chen et al., J Immunol 2008 : Proteasome inhibitors enhance TRAIL induced apoptosis through the intronic regulation of DR5 : involvement of NF-kappa B and reactive oxygen species mediated p53 activation
Rasmussen et al., Inflamm Res 2008 (Inflammation) : We studied NF-kappaB activation and the induction of interleukin 8 (IL-8) and p53 gene expression in an interleukin 1beta (IL-1beta) stimulated HepG2 cell line ... NF-kappaB induced IL-8 and p53 protein production was studied using specific siRNA, an IkappaB kinase 2 inhibitor, and mitogen activated protein kinase ( MAPK ) inhibitors
Króliczak et al., Acta biochimica Polonica 2008 (Neoplasms) : Sp1 and NFkappaB binding to the probes resembling their putative binding sites present in the S100A6 promoter was decreased in the presence of wild type p53
Tsoporis et al., J Biol Chem 2008 (Inflammation) : These results demonstrate that S100A6 is induced by tumor necrosis factor-alpha via an NF-kappaB dependent mechanism, serving a role in homeostasis to limit tumor necrosis factor-alpha induced apoptosis by regulating p53 phosphorylation
Dey et al., Nat Rev Drug Discov 2008 (Neoplasms) : Although drugs are being designed to selectively activate p53 or inhibit NF-kappaB , there is no concerted effort yet to deliberately make drugs that can simultaneously do both
Suzuki et al., Am J Respir Cell Mol Biol 2009 : NF-kappaB inhibitors also reduced p53 phosphorylation
Liu et al., J Immunol 2009 (Acute Lung Injury) : These data demonstrate that p53 regulates NF-kappaB activity in inflammatory cells and suggest that modulation of p53 may have potential therapeutic benefits in acute inflammatory conditions, such as ALI
Rath et al., DNA Cell Biol 2009 (Lung Neoplasms) : We show that expression of wt-p53 from a recombinant adenovirus-p53 followed by treatment with 2-methoxyestradiol ( 2-ME ), an endogenous, nontoxic, estrogenic metabolite, resulted in differential NF-kappaB activation and inhibitor kappaB alpha ( IkappaB-alpha ) degradation in three different human lung cancer cell lines with different p53 phenotypes ... In contrast, either adeno-p53 expression or 2-ME treatment induced NF-kappaB activation in the p53 deleted H1299 cells, but H460 cells, containing wt-p53, did not show NF-kappaB activation under any of these conditions
Meylan et al., Nature 2009 (Adenocarcinoma...) : Concomitant loss of p53 ( also known as Trp53 ) and expression of oncogenic Kras ( G12D ) resulted in NF-kappaB activation in primary mouse embryonic fibroblasts
Mangolini et al., Apoptosis 2010 (Polycystic Kidney, Autosomal Recessive) : FC1-depletion also induced reduction in ERK1/2 kinase activation, upregulation of the pro-apoptotic protein p53 and activation of NF-kappaB , a transcription factor which reduces apoptosis in many organs and tissues
Kamal et al., Bioorg Med Chem 2010 : Therefore, the data generated suggests that these PBD conjugates activate p53 and inhibit NF-kappaB and thereby these compounds could be promising anticancer agents with better therapeutic potential for the suppression of tumours
Wang et al., Eur J Neurosci 2009 : These results suggest that overstimulation of NMDA receptors can induce NF-kappaB dependent expression of p53
Schneider et al., Oncogene 2010 : Experiments with knockout cells show that p65 and p53 are both required for enhanced NF-kappaB activity during S-phase checkpoint activation involving ataxia-telangiectasia mutated and checkpoint kinase-1 ... Hence, p53 is unexpectedly necessary for NF-kappaB mediated gene expression induced by atypical and classical stimuli
Li et al., Toxicological sciences : an official journal of the Society of Toxicology 2010 (Cell Transformation, Neoplastic) : The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite ... Together, the results suggest that the repressive effect of NF-kappaB on p53 by mot-2 leads to genomic instability, which is involved in arsenite induced malignant transformation of human keratinocytes
Hong et al., Neuroscience bulletin 2010 (Brain Ischemia) : In addition, p53 disrupts NF-kappaB binding to p300 and blocks NF-kappaB mediated survival signaling
Gudkov et al., J Clin Invest 2010 : Progress in understanding differences in the mechanisms involved in the responses of normal and tumor cells to genotoxic stress has led to the development of new rational approaches to selective protection of normal cells, such as suppression of apoptosis by pharmacological inhibition of p53 or activation of NF-kappaB
Johnson et al., Cancer Res 2011 : Translocation of the NF-?B family member RelA to mitochondria was inhibited by p53 by blocking an essential interaction with the HSP Mortalin
Ghose et al., PloS one 2011 (Huntington Disease) : We conclude that ( i ) miR-125b and miR-150 target p53, which in turn regulates RelA/NFkB and miR-146a expressions ; ( ii ) reduced miR-125b and miR-150 expressions, increased p53 level and decreased RelA/NFkB and miR-146a expressions originate from mutant HTT ( iii ) p53 directly or indirectly regulates the expression of miR-146a
Fouad et al., Pak J Biol Sci 2011 (Necrosis) : The regulation of p53 expression is mediated by the transcription factor NF-kappaB
Sun et al., Mol Cell Biol 1995 : Although a kappa B motif partially overlaps with this element and those genotoxic agents activate NF-kappa B, it does not play a major role in p53 genotoxic stress response : NF-kappa B p65 expression did not induce significant p53 promoter activation, and NF-kappa B inhibitors ( N-acetyl cysteine and I kappa B alpha ) did not inhibit genotoxic stress-inducible p53 promoter activation
Wu et al., J Biol Chem 1994 : NF-kappa B activation of p53 ... Thus, we show that NF-kappa B activates p53 and that this activation is inducible by TNF-alpha ... Since NF-kappa B induction occurs as a response to stress and p53 arrests cells in G1/S, where repair may be initiated, activation of p53 by NF-kappa B could be a mechanism by which cells can recover from stress
Hellin et al., Oncogene 1998 (Colonic Neoplasms) : Under our conditions, the free radical scavengers NAC and PDTC were not able to block NF-kappaB activation or p53 induction , indicating that reactive oxygen intermediates were not involved in the cellular response to daunomycin stimulation
Taylor et al., Biochemistry (Mosc) 1998 (Acute-Phase Reaction...) : iNOS expression requires the transcription factor NF-kappaB and is down-regulated by steroids, TGF-beta, the heat shock response, p53 , and nitric oxide ( NO ) itself
Ravi et al., Cancer Res 1998 : p53 mediated repression of nuclear factor-kappaB RelA via the transcriptional integrator p300 ... p53 mediated repression of RelA is relieved by p300 overexpression and the increased RelA activity conferred by p53-deficiency is counteracted by either transactivation domain-deficient p300 fragments that bind RelA or a transdominant mutant of IkappaB alpha
Wadgaonkar et al., J Biol Chem 1999 : Increased levels of the coactivator relieve p53 mediated repression of NF-kappaB activity and p65 mediated repression of p53 dependent gene expression