Gene interactions and pathways from curated databases and text-mining

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CDH13 — RELA

Text-mined interactions from Literome

Soloviev et al., J Orthop Res 2002 : The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles
Li et al., Biochem Biophys Res Commun 2003 : Overexpression of p105 and IkappaBgamma inhibited Casper induced NF-kappaB activation and potentiated Casper induced apoptosis
Fu et al., J Biol Chem 2004 : We showed that p105 ( sr ), which no longer generates p50 and undergoes signal induced degradation, effectively inhibits all NF-kappaB activities
Paya et al., Proc Natl Acad Sci U S A 1992 : These observations indicate that during chronic HIV infection of U937 cells, continuous NF-kappa B ( p50/p65 ) translocation results in p105 promoter upregulation with subsequent cytosolic NF-kappa B accumulation, ready for further translocation
Cohen et al., Biochem Biophys Res Commun 2009 : p105 plays dual roles in NF-kappaB signaling : in its precursor form it inhibits NF-kappaB activation, but limited processing by the ubiquitin system generates the p50 active subunit of the transcription factor
McElhinny et al., J Virol 1995 (HIV Infections) : Transcriptional activity of p105 is also increased in infected cells and is also mediated by NF-kappa B through a specific kappa B motif
Ishikawa et al., Oncogene 1996 : Loss of p105 and the augment of total p50 produced an increase in the nuclear kappa B-binding activity of p50-RelA and p50 dimers
Ishikawa et al., J Exp Med 1998 (Inflammation...) : Loss of p105 also led to enhanced constitutive p50 homodimer and inducible NF-kappaB activities in unstimulated and stimulated cells, respectively