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BMP6 — IL6

Text-mined interactions from Literome

Ahmed et al., Cell Biol Int 2001 : Also, the effect of BMP-6 on marrow stroma production of interleukin-6 , -11 and their common receptor gp130 that is expressed in haemopoietic stem cells and is indispensable for their proliferation and tri-lineage differentiation was examined
Namba et al., Connect Tissue Res 2007 : We examined the effect of IL-6 and sIL-6Ralpha on cell growth, alkaline phosphatase ( ALPase ) activity, and the expression of Sox-9, type II collagen, aggrecan core, link protein, BMP-7 , and BMP receptors in human chondrocytes ... The expression of Sox-9 and aggrecan core did not change in the presence or absence of IL-6 and sIL-6Ralpha, whereas the expression of type II collagen, link protein, BMP-7 , and BMP receptors increased in the presence of both IL-6 and sIL-6Ralpha ... These results suggest that IL-6 and sIL-6Ralpha suppress the differentiation of chondrocytes and induce the repair of arthrodial cartilage through an increase in the expression of cartilage matrix proteins, BMP-7 , and BMP receptors in the cells
Yu et al., Nat Chem Biol 2008 : In vitro, dorsomorphin inhibited BMP- , hemojuvelin- and interleukin 6-stimulated expression of the systemic iron regulator hepcidin, which suggests that BMP receptors regulate hepcidin induction by all of these stimuli
Lee et al., J Biol Chem 2010 : Induction of interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways ... Here, we report that BMP-6 induces the expression of IL-6 in macrophages ... Using overexpression and knockdown experiments, we demonstrate that BMP receptor type II and activin-like kinase-2 are necessary for IL-6 induction by BMP-6
Ciuclan et al., Am J Respir Crit Care Med 2011 (Acute Disease...) : Molecular analysis showed a dysregulated transforming growth factor-ß/bone morphogenetic protein/Smad axis in SU5416- and/or hypoxia treated mice as well as augmented induction of IL-6 and Hif-1a levels