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CDKN1A — CNTN2
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de La Fuente et al., J Virol 2000
(HTLV-I Infections...) :
Wild-type but not a mutant form of
Tax ( M47 )
transactivated the
p21/waf1 promoter in a p53 independent manner and utilized a minimal promoter that contained E2A and TATA box sequences
de La Fuente et al., AIDS Res Hum Retroviruses 2000
:
We found that the minimal
p21/waf1 promoter ( -49 to +49 sequence ) was
activated by
Tax and the minimal promoter contained two E2A transcription factor binding sites located between the TATA box and the initiation site
Chowdhury et al., Int J Cancer 2003
:
We investigated the possible
involvement of HTLV-1
Tax in the transcriptional activation of
p21/Waf1/Cip1 ( hereafter p21 ), a potent inhibitor of cyclin dependent kinases and cell growth ... CREB/ATF defective
Tax mutant ( M47 )
activated the
p21 promoter significantly less efficiently ...
Tax activated wild type ( wt )
p21 promoter in p53 negative Jurkat and p53 positive A301cells, irrespective of endogenous p53 status, and activated a mutant p21 promoter containing a p53 responsive element (p53RE) deletion as strongly as wt promoter ... Of importance, cdk2 activity was almost completely abolished in Tax induced p21 expressing MT-2 cells, suggesting that
Tax induced
p21 predominantly affects the activity of cdk2, a late G1 and S phase kinase ... Taken together, these findings suggest that HTLV-1
Tax activates
p21/Waf1/Cip1 , a cell growth inhibitor, in a p53 independent mechanism through CREB/ATF related transcription factors, and inhibits cdk2 ...
Tax induction of
p21 may balance the T-cell proliferation function of Tax and may contribute to the long clinical latency of HTLV-1 infection and the delayed development of adult T-cell leukemia
Sieburg et al., J Virol 2004
:
Tax1 markedly
activated transcription from the cdk inhibitor
p21 ( cip1/waf1 ) promoter in comparison to Tax2, suggesting that upregulation of p21 ( cip1/waf1 ) may account for the differential inhibition of cellular replication kinetics displayed by Tax1/Jurkat and Tax2/Jurkat cells
Kuo et al., EMBO J 2006
(Cell Transformation, Viral) :
These results indicate that APC activation by
Tax causes inactivation of SCF ( Skp2 ) and stabilization of
p21 ( CIP1/WAF1 ) and p27 ( KIP1 )
Akagi et al., Oncogene 1996
(Leukemia, T-Cell) :
Expression of cell-cycle regulatory genes in HTLV-I infected T-cell lines : possible
involvement of
Tax1 in the altered expression of cyclin D2, p18Ink4 and
p21Waf1/Cip1/Sdi1
Cereseto et al., Blood 1996
(Cell Transformation, Viral) :
Additionally,
Tax induces upregulation of a p21waf1/cip1 promoter-driven luciferase gene in p53 null cells, and
increases p21waf1/cip1 expression in Jurkat T cells