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STAT3 — TPO
Text-mined interactions from Literome
Yang et al., Blood 1999
:
In addition, hG-CSF
induced phosphorylation of
STAT3 but not Jak2 or STAT5, while
TPO induced phosphorylation of both
Wang et al., Blood 2000
:
It was found that IFN-alpha directly suppresses
TPO induced phosphorylation of the JAK2 substrates c-Mpl and STAT 5 in a TPO dependent hematopoietic cell line and of Mpl and
STAT3 in primary murine MK
Kalina et al., Exp Hematol 2001
(Leukemia, Erythroblastic, Acute...) :
Although
STAT3 also was
activated by
TPO , STAT3 activation remained unaltered by TGF-beta1
Kirito et al., Blood 2002
:
In addition, it was found that
Stat3 activation
induced by
TPO stimulation was drastically suppressed in these Tg mice compared with littermates
Piu et al., Oncogene 2002
:
Similarly, G-CSF and
TPO lead to activation of
STAT3 and STAT5 but, unlike the betac cytokine receptors, both stimulated cellular growth
Tong et al., J Exp Med 2004
:
The absence of Lnk caused enhanced and prolonged
Tpo induction of
STAT3 , STAT5, Akt, and MAPK signaling pathways in CD41+ megakaryocytes
Segerer et al., Mol Hum Reprod 2013
:
Studying the signalling pathway proteins in the uNK cells, an
activation of
STAT3/Tyr by
TPO , was detected
Bacon et al., FEBS Lett 1995
(Leukemia, Megakaryoblastic, Acute) :
Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and
STAT3
Pallard et al., EMBO J 1995
(Leukemia, Megakaryoblastic, Acute) :
We demonstrated that
TPO activates the kinase JAK2 and a STAT5-like transcriptional factor but not STAT1, STAT2,
STAT3 or STAT4, in a very rapid and transient manner
Matsumura et al., Mol Cell Biol 1997
(Leukemia, Megakaryoblastic, Acute) :
Furthermore, we found that although
TPO induced tyrosine phosphorylation of both
STAT3 and STAT5 in CMK cells, only STAT5 showed binding activities to potential STAT binding sites that locate in the promoter region of p21 gene ( p21-SIE sites ), thereby leading to transactivation of p21
Miura et al., Acta Haematol 1998
(Leukemia...) :
In UT-7/GM cells, EPO activated Stat5 alone, although the activation of Stat1 alpha,
Stat3 , and Stat5 was
induced by GM-CSF or
TPO