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AIFM1 — PARP1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: AIFM1 → PARP1 (increases, PARP1 Translocation, AIFM1 Activity) Xu et al., J Biol Chem 2006*
  Evidence: We found, based on genetic knockouts and pharmacological inhibition, that c-Jun N-terminal kinase (JNK), especially JNK1, but not the other groups of mitogen-activated protein kinase, is required for PARP-1-induced mitochondrial dysfunction, apoptosis-inducing factor translocation, and subsequent cell death.

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 306 proteins (association, pull down) Komarova et al., Mol Cell Proteomics 2011
• IRef Intact Interaction: Complex of 103 proteins (association, anti tag coimmunoprecipitation) Yang et al., J Proteome Res 2010