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FGFR3 — PVR

Text-mined interactions from Literome

el-Kashef et al., J Appl Physiol 1991 : At normal vascular tone, ACh ( 1-5 mumol ) produced a dose dependent increase in pulmonary arterial pressure ( Ppa ), total pulmonary vascular resistance (PVR) , and downstream resistance ( Rds ) without altering upstream resistance ( Rus ) ... These results suggest that 1 ) ACh increases PVR in the dog by constricting the venous segments ( downstream ) of the pulmonary circulation via activation of pulmonary vascular muscarinic receptors under conditions of both normal and elevated vascular tone, 2 ) both M1- and non-M1-muscarinic receptor subtypes appear to participate in mediating the ACh induced increase in Rds, and 3 ) ACh moderately relaxes the upstream ( arterial ) vessels, especially under conditions of elevated tone
el-Kashef et al., Pulm Pharmacol 1991 : In anesthetized rabbits, ACh ( 5-20 nmol/kg, i.v. ) increased pulmonary vascular resistance (PVR) and decreased systemic arterial pressure (SAP) ... After 2.85 nmol/kg i.v. pirenzepine ( PNZ ), the ACh induced increase in PVR was attenuated by 67 % while the decrease in SAP was not altered ... After 2.85 mumol/kg i.v. pirenzepine, the ACh induced increase in PVR was totally blocked, while the SAP response was only partially inhibited ( 43 % ) ... Atropine or secoverine ( SEC ) inhibited equally the PVR and SAP responses to ACh ... In isolated rabbit lungs perfused in situ at 140 ml/min, ACh ( 1 microM ) increased PVR by 210 %, perfusate levels of TXB2 by 1000 % and 6-keto-PGF1 alpha by 21 % of baseline values ... PNZ ( 50 nM ) inhibited the effects of ACh on PVR , TXB2 and 6-keto-PGF1 alpha levels ... SEC ( 50 nM ) did not alter the effects of ACh on PVR , or the TXB2 to 6-keto-PGF1 alpha ratio
Gordon et al., J Appl Physiol 1995 (Anoxia) : During 4 % O2 ventilation, baseline pulmonary vascular resistance (PVR) and the dilator response to both ACh and SNP were greater in 2D lungs
Defouilloy et al., Am J Respir Crit Care Med 1998 (Anoxia...) : In the 21 patients, negative correlations with Hb concentrations were found for ACh induced changes in PVR ( r = -0.57, p < 0.01 ), Ppa ( r = -0.46, p < 0.01 ), CI ( r = -0.5, p < 0.05 ), PaO2 ( r = -0.79, p < 0.01 ), and Qs/Qt ( r = -0.79, p < 0.01 )