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HRAS — MAP2K2

Pathways - manually collected, often from reviews:

• Reactome Reaction: MAP2K2 → HRAS (reaction)
• Reactome Reaction: MAP2K2 → HRAS (indirect_complex)
• WikiPathways Insulin Signaling: RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 → MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 (activation)
  

Text-mined interactions from Literome

Gopalbhai et al., J Cell Physiol 1998 (Cell Transformation, Neoplastic) : In contrast, expression of Raf22w, v-Ha-Ras , or v-Src resulted in the constitutive activation of the upstream kinases MEK1 and MEK2
Lafont et al., Biochem Pharmacol 1998 : ERK-2 is activated via a kinase cascade initiated by activation of the G protein p21Ras followed by phosphorylation and activation of Raf-1 and mitogen activated protein kinase kinase-1 ( MEK-1 )