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IRF6 — NOS1

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Lee et al., Arch Pharm Res 1999 : The effects of higenamine, a tetrahydroisoquinoline compound, on induction of NOS by bacterial lipopolysaccharide (LPS) were examined in murine peritoneal macrophages
Pugliese et al., Cell Biochem Funct 1999 (Aspergillosis) : Moreover, Escherichia coli lipopolysaccharide (LPS) , known to be a potent NOS inducer, increased NOS activity in our experimental model as well
Greenberg et al., Alcohol 1999 : Ethanol metabolism is not required for inhibition of LPS stimulated transcription of inducible nitric oxide synthase
Wanner et al., Langenbecks Arch Surg 1999 (Endotoxemia) : To further clarify the underlying mechanisms, rG-CSF treated liver cells were tested for the LPS induced gene expression of cytokine induced neutrophil chemoattractant ( CINC ) and intercellular adhesion molecule-1 ( ICAM-1 ) as potential chemotactic and leukocyte recruiting factors and for the gene expression of inducible nitric oxide synthase ( NOS II ) as potential modulator of leukocyte adherence
Song et al., Zhongguo Yao Li Xue Bao 1998 : To study the effect of dBcAMP on bacterial endotoxin LPS induced NOS activity
Zhu et al., Life Sci 1999 (Infarction, Middle Cerebral Artery...) : Nimodipine inhibited the Ca2+ independent NOS activity induced by lipopolysaccharide (LPS) + tumor necrosis factor alpha (TNF alpha) in mouse astroglial cells with an IC50 value of 0.036+/-0.003 mM and Ca2+ dependent NOS activity in mouse neurons with an IC50 value of 0.047+/-0.003 mM, but did not affect Ca2+ dependent NOS activity in BCECs
Uribe et al., Endocrinology 1999 : LPS induced Ca2+ dependent NOS activity in the PVN as well as the number of PVN cells expressing citrulline ( a compound produced stoichiometrically with NO ) also increased significantly over a time course that corresponded to ACTH and corticosterone release
Paik et al., J Biol Chem 2000 (Adenocarcinoma...) : Flufenamic acid and 15-deoxy-Delta ( 12,14 ) -prostaglandin J ( 2 ) also inhibit LPS induced expression of inducible form of nitric-oxide synthase and interleukin-1alpha in RAW 264.7 cells
Kamerman et al., Life Sci 2000 (Fever) : We investigated the effect of N-nitro-L-arginine methyl ester ( L-NAME ), an unspecific nitric oxide synthase (NOS) inhibitor, and aminoguanidine, a relatively selective inhibitor of the inducible NOS enzyme, on both gram negative lipopolysaccharide (LPS) and gram positive muramyl dipeptide ( MDP ) fever in guinea pigs
Cymeryng et al., Endocr Res 2000 : The induction of nitric oxide synthase (NOS) II by bacterial lypopolysaccharide (LPS) was studied in a steroidogenic mouse tumor adrenal cell line ( Y1 )
Franchi et al., Nitric Oxide 2001 : When LC and LPS were injected simultaneously 6 h before sacrifice, a significant decrease in LPS induced NOS activity was observed ... In short, LC is a NSAID with inhibitory action on the expression of LPS induced NOS , effect that was not seen with INDO in our experimental conditions
Heiss et al., J Biol Chem 2001 : Western blot analyses revealed time- and dose dependent reduction of LPS induced inducible nitric-oxide synthase as well as Cox-2 protein expression, which was suppressed at the transcriptional level
Lomniczi et al., Am J Physiol Endocrinol Metab 2001 : These results indicate that LPS activates NOS , leading to NO release, which activates COX, generating PGEs that act back to further activate NOS, causing further generation of PGEs by activation of COX
Matsuzaki et al., J Nutr 2001 : The LPS induced expression of inducible nitric oxide synthase in the liver was significantly suppressed by the energy restriction
Javeshghani et al., Shock 2001 (Shock, Septic) : Calcium dependent NOS activity increased with LPS in the aorta and vena cava but decreased in pulmonary artery at 4 h
Wang et al., Chin Med J (Engl) 1999 (Intussusception) : Furthermore, LPS increased total NOS activity, NOx production and cGMP levels in plasma or in colic smooth muscle tissues
Kizaki et al., Biochem Biophys Res Commun 2001 : Negative regulation of LPS stimulated expression of inducible nitric oxide synthase by AP-1 in macrophage cell line J774A.1
Evdokimova et al., Toxicol In Vitro 2002 : Nitrites formation was used as an indirect way to assess LPS mediated activation of nitric oxide synthase ( iNOS, type 2 )
Helmer et al., Gastroenterology 2002 (Endotoxemia) : Lipopolysaccharide (LPS) enhanced the expression and activity of inducible nitric oxide synthase in gastric mucosa in a dose- and time dependent manner
Plum et al., Nephron 2002 (Peritonitis) : Prostacyclin enhances the expression of LPS/INF-gamma induced nitric oxide synthase in human monocytes
Li et al., Respir Res 2002 : Activation of macrophage nuclear factor-kappa B and induction of inducible nitric oxide synthase by LPS
Chano et al., Eur J Immunol 2002 : We have previously shown that overexpression of a dominant negative ( DN ) mutant of protein kinase C-alpha (PKC-alpha) in RAW 264.7 macrophages inhibited lipopolysaccharide (LPS) induced IL-1alpha, inducible nitric oxide synthase and cyclooxygenase-2 expression
Orliac et al., J Pharmacol Exp Ther 2003 (Endotoxemia...) : LPS treatment induced a 3-fold increase in total nitric-oxide synthase (NOS) activity without modifying either the systolic blood pressure or the vascular reactivity to NE of the isolated mesenteric bed
Sorimachi et al., Cancer Detect Prev 2003 : As reported previously, stimulation of macrophages by EP3 or LPS dramatically induced the expression of IL-8, NOS , and TNF-alpha mRNAs
Ogando et al., Reproduction 2003 (Bacterial Infections...) : LPS increased iNOS expression in decidual and myometrial cells and increased nNOS expression in decidual cells
Hsiao et al., Biochem Pharmacol 2003 (Shock, Septic) : A novel antioxidant, octyl caffeate, suppression of LPS/IFN-gamma induced inducible nitric oxide synthase gene expression in rat aortic smooth muscle cells
Galea et al., Proc Natl Acad Sci U S A 1992 : LPS also induces NOS in C6 glioma cells and microglial cultures but not in cultured cortical neurons
Kristof et al., J Biol Chem 2003 (Inflammation) : The role of mTOR and PI3K in the activation of human inducible nitric oxide synthase transcription by cytokines and lipopolysaccharide (LPS) was investigated in lung epithelial adenocarcinoma ( A549 ) cells ... LY294002, a dual mTOR and PI3K inhibitor, blocked human inducible nitric oxide synthase ( hiNOS ) promoter activation and mRNA induction by cytokines and LPS in a PI3K independent fashion
Hortelano et al., J Biol Chem 1992 : Incubation of cells with alpha-phorbol 12,13-didecanoate failed to counteract the effect of LPS or to induce nitric oxide synthase , suggesting that activation of protein kinase C was involved in this process
Lee et al., Neurosci Lett 2003 (Brain Ischemia...) : Cell death was inhibited when the slice was co-treated with both LPS and N-monomethyl-L-arginine, a nitric oxide synthase inhibitor
Mitchell et al., Mol Pharmacol 1992 : Lipopolysaccharide (LPS) , either alone or in combination with cytokines, induces nitric oxide ( NO ) synthase activity in cells that normally release little or no NO
Simmons et al., J Neurochem 1992 : N18 cells demonstrated constitutive Ca ( 2+ ) -dependent NOS-like activity that was not enhanced by LPS induction
Suuronen et al., J Neurochem 2003 (Inflammation) : TSA clearly potentiated the LPS induced expression of interleukin (IL)-6 and inducible nitric oxide synthase mRNAs, as well as the secretion of cytokines IL-6, tumour necrosis factor-alpha and macrophage inflammatory protein (MIP)-2, and nitric oxide ( NO )
Brock et al., Prostaglandins Other Lipid Mediat 2003 : In addition to COX-2, nitric oxide synthase (NOS) was also induced by LPS ... In addition to COX-2, nitric oxide synthase (NOS) was also induced by LPS
Lee et al., Biochem Pharmacol 2003 : Similarly, these compounds also suppressed the LPS induced inducible nitric oxide synthase expression and nitric oxide production
Wang et al., J Pharmacol Exp Ther 2004 (Inflammation...) : Furthermore, ANDRO dose-dependently attenuated LPS induced inducible nitric-oxide synthase and cyclooxygenase-2 protein expression in BV-2 microglia, as determined by Western blot
Giri et al., J Neurosci 2004 (Inflammation) : A pharmacological activator of AMPK, 5-amino-4-imidazole carboxamide riboside ( AICAR ) inhibited lipopolysaccharide (LPS) induced expression of proinflammatory cytokines ( tumor necrosis factor alpha, interleukin-1beta, and interleukin-6 ) and inducible nitric oxide synthase in primary rat astrocytes, microglia, and peritoneal macrophages
Ogando et al., Neuroimmunomodulation 2004 : The stimulatory effect of LPS and estrogen on NOS activity is exerted on the Ca-independent isoform and IL-10 in vitro abolished this increase
Wideman et al., Poult Sci 2004 (Hypertension, Pulmonary...) : LPS induces the expression of nitric oxide synthase ( iNOS ), which produces the vasodilator nitric oxide ( NO ) to modulate the responses to concurrently produced vasoconstrictors
Ribeiro et al., Neuroimmunomodulation 2004 (Embryo Loss...) : To study the effect of LPS and to characterize the isoenzymes involved in the process, specific inhibitors of iNOS ( aminoguanidine ) and COX-II ( meloxicam, nimesulide ) and non-specific of COX ( indomethacin ) were injected intraperitoneally to determine their effect on NO and PG production, and on NOS and COX expression induced by LPS in estrogenized rat uterus
Vega et al., J Leukoc Biol 2004 : This report focuses on the modulatory role of endogenous H ( 2 ) O ( 2 ) on lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma) induced inducible nitric oxide synthase ( NOS2 ) gene expression in rat peritoneal macrophages
Kang et al., J Pharmacol Exp Ther 2004 (Cystitis...) : Increases in urinary cyclic GMP, NOS activity, and eNOS protein and phosphorylation 1 h after induction of inflammation with LPS , indicate that eNOS plays a role in the early response to bladder inflammation
Wideman et al., Poult Sci 2004 (Hypertension, Pulmonary...) : Previous in vitro studies conducted using macrophages from different lines of chickens demonstrated innate variability in the LPS stimulated induction of nitric oxide synthase ( iNOS ) followed by the onset of an LPS-refractory state
Palomba et al., J Biol Chem 2004 : Previous results have indicated that lipopolysaccharide (LPS) plus interferon-gamma (IFNgamma) inhibits nitric-oxide synthase (NOS)-I activity in glial cells
Elferink et al., Am J Physiol Gastrointest Liver Physiol 2004 (Drug-Induced Liver Injury) : In liver slices from both species, LPS induced expression of inducible nitric oxide synthase was detected within 1-3 h and remained increased over 24 h
Kim et al., Neuropharmacology 2004 : In this study, we found that a new compound KL-1037 suppressed LPS induced NO release/inducible nitric oxide synthase expression in BV2 mouse microglial cells
Shin et al., FEBS Lett 2004 (Inflammation) : Furthermore, the compound inhibited not only LPS induced expressions of tumor necrosis factor-alpha, interleukin (IL)-1beta, IL-6 and inducible nitric oxide synthase and cyclooxygenase-2 but also LPS induced apoptosis of the RAW 264.7 cells
Nakajima et al., J Biol Chem 2004 (Inflammation) : PARP-1 inhibitors and the antisense RNA for PARP-1 mRNA suppressed lipopolysaccharide (LPS) induced expression of tumor necrosis factor-alpha and inducible nitric-oxide synthase , suggesting that PARP-1 activity has a critical role in synthesis
Cho et al., Int Immunopharmacol 2004 : Previously, we showed that arctigenin potently inhibited the induction of nitric oxide synthase ( iNOS ) by lipopolysaccharide (LPS) , which involved suppression of NF-kappaB activation
Paintlia et al., J Neurosci Res 2004 (Demyelinating Diseases...) : Intraperitoneal pretreatment of pregnant female rats with NAC ( 50 mg/kg ), 2 hr prior to administration of LPS at embryonic day 18 ( E18 ), attenuated the LPS induced expression of inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1beta, and inducible nitric oxide synthase in fetal rat brains
Lee et al., J Biol Chem 2004 (Inflammation) : We found that TGase 2 activates the transcriptional activator nuclear factor (NF)-kappaB and thereby enhances LPS induced expression of inducible nitric-oxide synthase
Zeidler et al., Proc Natl Acad Sci U S A 2004 : Interestingly, LPS did not activate the pathogen-inducible varP NOS , but AtNOS1, a distinct NOS previously associated with hormonal signaling in plants
Kim et al., Biochem Biophys Res Commun 2005 : Protein expression of inducible nitric oxide synthase and cyclooxygenase-2, and production of NO by these cells were induced by LPS or IFN-gamma
Shen et al., Neurochem Int 2005 (Encephalitis...) : Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells
Hamby et al., J Neurosci Methods 2006 : Purified monolayers appeared morphologically normal 24h after LME treatment and expressed nitric oxide synthase-2 (NOS-2) and cyclooxygenase-2 (COX-2) proteins upon stimulation with LPS plus IFNgamma, albeit to a lower level than unpurified monolayers
Lee et al., J Pharmacol Exp Ther 2006 : LPS induced production of TNF-alpha and NO as well as expression of inducible nitric-oxide synthase and cyclooxygenase-2 was significantly suppressed by the treatment of cardamomin in RAW264.7 cells
Martin et al., J Pharmacol Exp Ther 2006 : Similar inhibition by A ( 3 ) AR was observed for LPS stimulated inducible nitric-oxide synthase
Nakaya et al., Biochem Pharmacol 2005 : Isoflavone genistein and daidzein up-regulate LPS induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells
Saito et al., J Pharmacol Sci 2005 : The purpose of this study was to investigate the effects of daunorubicin on lipopolysaccharide (LPS) stimulated inducible-type nitric oxide synthase ( iNOS ) expression in macrophages
Kamoun et al., Hepatology 2006 : Antagonizing ET-1 effects and blocking its activation in LPS pretreated SECs decreased the LPS induced overexpression of CAV-1 as well as the inhibition of ET-1 induced NOS activity
Jiang et al., Nitric Oxide 2006 : The LPS stimulated NOS activity kept constant during the experiment ... More importantly, an apparent increase of LPS stimulated NOS activity was observed in M. japonicus at 48 h postchallenge, which was about 4 times higher than that in the control group of health shrimps
Kim et al., Planta Med 2006 : Luteolin inhibits LPS stimulated inducible nitric oxide synthase expression in BV-2 microglial cells
Kim et al., Biochem Biophys Res Commun 2006 (Inflammation) : It also decreases LPS induced expression of inducible nitric oxide synthase and production of nitric oxide, and reduces LPS induced secretion of tumor necrosis factor-alpha and monocyte chemoattractant protein-1
Cella et al., Eur J Pharmacol 2006 : The present work shows that LPS augmented NOS activity 3 h post-treatment and iNOS expression earlier, 2 h post-administration
Yan et al., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006 : Compared with normal saline, LPS significantly induced the upregulation of iNOS protein expression in the cultured ECV-304 cells, and NOS activity in ECV-304 cells and NO level in cultured media were increased
Suh et al., Am J Respir Cell Mol Biol 2006 : CO also decreased LPS induced nitric oxide synthase-2 protein expression and nitrite production, and decreased LPS induced activation of protein binding to C/EBP consensus oligonucleotides of murine nitric oxide synthase-2 promoter
Munger et al., Am J Physiol Regul Integr Comp Physiol 2006 : Acute renal response to LPS : impaired arginine production and inducible nitric oxide synthase activity
Dal Secco et al., Nitric Oxide 2006 : The NOS inhibitors did not enhance LPS- , Cg- or fMLP induced migration and adhesion in ICAM-1-/- mice
Mohammad et al., Int Immunol 2006 (Diabetes Mellitus, Experimental) : Dysregulation of TLR4 expression in the diabetic state correlated with increased nuclear factor kappa B (NF-kappaB) activation in response to the TLR4 ligand LPS and higher expression of IL-12p40, tumor necrosis factor alpha (TNFalpha), IL-6 and inducible nitric oxide synthase but lowered expression of IL-10
Santodomingo-Garzón et al., Br J Pharmacol 2006 (Hyperalgesia...) : The antinociceptive effect of atorvastatin upon LPS- or PGE ( 2 ) -induced hypernociception was prevented by non-selective inhibitors of nitric oxide synthase (NOS) but not by selective inhibition of inducible NOS or in mice lacking this enzyme
Naureckiene et al., J Pharmacol Toxicol Methods 2007 : We also demonstrate that LPS stimulation of the mouse macrophage cell line RAW 264.7 induces the expression of iNOS, but not nNOS or eNOS, at the levels of mRNA transcription and protein expression
Sunday et al., Am J Physiol Heart Circ Physiol 2007 (Vasculitis, Central Nervous System) : In 4-mo-old rats, estrogen also significantly suppressed LPS induction of inducible nitric oxide synthase and cyclooxygenase-2 proteins, as well as production of nitric oxide and PGE ( 2 )
Skorokhod et al., Malaria journal 2007 (Malaria) : Malarial pigment haemozoin, IFN-gamma, TNF-alpha, IL-1beta and LPS do not stimulate expression of inducible nitric oxide synthase and production of nitric oxide in immuno purified human monocytes
Grion et al., J Endocrinol 2007 : The present study was designed to investigate the effect of lipopolysaccharide (LPS) on the expression levels and activities of the nitric oxide synthase (NOS) and heme oxygenase ( HO ) systems in the rat adrenal gland
Arai et al., Acta Otolaryngol 2008 : Induction of inducible nitric oxide synthase and apoptosis by LPS and TNF-alpha in nasal microvascular endothelial cells
McMaster et al., Br J Pharmacol 2008 : Cigarette smoke extract also inhibited nitric oxide synthase II protein expression in response to LPS
Kim et al., J Microbiol Biotechnol 2007 : LADI dose-dependently inhibited lipopolysaccharide (LPS) induced upregulation of inducible nitric oxide synthase and the production of nitric oxide in RAW 264.7 murine macrophages
Liang et al., J Biol Chem 2008 (Inflammation) : Further studies demonstrated that MCPIP1 did not directly affect the mRNA stability of tumor necrosis factor alpha and monocyte chemoattractant protein 1 ( MCP-1 ) but strongly inhibited LPS induced tumor necrosis factor alpha and inducible nitric-oxide synthase promoter activation
Kizaki et al., Immunology 2008 : Both LPS stimulated inducible nitric oxide synthase ( NOS II ) expression and NO production were markedly suppressed in the RAWar cells
Ward et al., Bioinorganic chemistry and applications 2003 : However inducible nitric oxide synthase activity was significantly reduced in these macrophages as shown by decreases in LPSinduced and LPS+IFNgamma induced NOS activation
Begum et al., J Pharmacol Exp Ther 2008 (Alzheimer Disease...) : Despite dramatically higher drug plasma levels after TC compared with curcumin gavage, resulting brain levels of parent compounds were similar, correlating with reduction in LPS stimulated inducible nitric-oxide synthase , nitrotyrosine, F2 isoprostanes, and carbonyls
Liu et al., FEBS Lett 2008 (Shock, Septic) : In the present study, we found that PTS2 dose-dependently inhibited the LPS induced up-regulation of nitric oxide synthase ( iNOS ) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells
Shi et al., Blood 2008 (Gram-Negative Bacterial Infections...) : Furthermore, rTMD1 modulated LPS induced mitogen activated protein kinase and nuclear factor-kappaB signaling pathway activations and inducible nitric oxide synthase expression in macrophages
Kim et al., J Microbiol Biotechnol 2008 : MEH and MW also inhibited the LPS induced inducible nitric oxide synthase expression
Cheng et al., J Ethnopharmacol 2008 : Shikonin derivatives inhibited LPS induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-kappaB signaling
Grasa et al., J Physiol Pharmacol 2008 : All of these isoforms were expressed constitutively and only the nNOS was reduced in the presence of LPS
Sande et al., Am J Pathol 2008 (Disease Models, Animal...) : In addition, melatonin significantly abrogated the LPS induced increase in retinal nitric-oxide synthase activity, tumor necrosis factor-alpha, and nuclear factor kappaB p50 and p65 subunit levels
Kim et al., Am J Physiol Gastrointest Liver Physiol 2009 (Disease Models, Animal...) : Liquiritigenin ( LQ ), an active component of licorice, has an inhibitory effect on LPS induced inhibitory nitric oxide synthase expression
Kallapur et al., Am J Respir Crit Care Med 2009 (Chorioamnionitis...) : rhIL-1ra decreased IA LPS induced lung inflammation assessed by decreased lung neutrophil and monocyte influx, inducible nitric oxide synthase expression, lung IL-6 and IL-1beta mRNA expression, and airway myeloperoxidase concentrations
Classen et al., Methods Mol Biol 2009 : NO synthase 2 (NOS2) is induced by IFN-alpha or LPS and degrades arginine into OH-arginine and then into NO
Li et al., Free Radic Biol Med 2009 (Shock, Septic) : GYY4137 inhibited LPS induced TNF-alpha production in rat blood and reduced the LPS evoked rise in NF-kappaB activation, inducible nitric oxide synthase/cyclooxygenase-2 expression, and generation of PGE ( 2 ) and nitrate/nitrite in RAW 264.7 macrophages
Ward et al., Dig Dis Sci 2010 (Bile Reflux...) : In the rat, laparotomy, done either before or after administration of LPS, attenuated LPS induced bile reflux, gastric bleeding, and cyclooxygenase-2, but not inducible nitric oxide synthase , expression when compared to controls given LPS
Sánchez-Lemus et al., Brain Behav Immun 2009 (Inflammation) : The ARB reduced LPS induced pituitary gene expression of IL-6, LIF, iNOS, COX-2 and IkappaB-alpha ; and prevented LPS induced increase of nNOS/eNOS activity
Fleisher-Berkovich et al., Peptides 2009 (Inflammation) : The data shows that both carnosine and N-acetyl carnosine significantly attenuated the LPS induced nitric oxide synthesis and the expression of inducible nitric oxide synthase by 60 % and 70 %, respectively
Kim et al., Eur J Clin Invest 2009 (Edema) : Our in vitro experiments showed that celastrol suppressed not only LPS stimulated generation of nitric oxide and prostaglandin E ( 2 ), but also expression of inducible nitric oxide synthase and cyclooxygenase-2 in RAW264.7 cells
Gerhäuser et al., Mol Nutr Food Res 2009 : We further identified aroma compounds as potent inhibitors of LPS induced inducible nitric oxide synthase activity in Raw 264.7 cell culture
Chang et al., Inflammation 2010 (Inflammation) : GLA significantly inhibited LPS induced protein expression of inducible nitric oxide synthase , pro-interleukin-1beta, and cyclooxygenase-2 as well as nitric oxide production and the intracellular glutathione level
Huang et al., J Agric Food Chem 2009 : LPS induced cyclooxygenase-2 (COX-2) and nitric oxide synthase ( iNOS ) protein expression were both attenuated by P. vulgaris ethanol extracts, whereas RA inhibited only COX-2 expression
Lee et al., Int Immunopharmacol 2010 : In RAW264.7 macrophage cells, saurolactam significantly inhibited the lipopolysaccharide (LPS) induced expression of inducible nitric oxide synthase and cyclooxygenase-2 and, consequently, inhibited the release of NO and prostaglandin E2
Yao et al., Nitric Oxide 2010 (Demyelinating Diseases...) : LPS mediated injury to oligodendrocytes is mediated by the activation of nNOS : relevance to human demyelinating disease ... We determined the activation and consequences of neuronal nitric oxide synthase (nNOS) following stimulation with LPS in the MO3.13 cell line
Lee et al., Biochem Biophys Res Commun 2010 : Consistent with these findings, alpha-iso-cubebenol also reduced the LPS induced expression of inducible nitric oxide synthase and cyclooxygenase-2 at the protein and mRNA levels in a concentration dependent manner
Chu et al., Food Chem Toxicol 2010 (Acute Lung Injury...) : Further, sesamol significantly inhibited LPS induced TNF-alpha, nitrite, inducible nitric oxide synthase expression, and nuclear factor-kappaB activation levels in primary alveolar macrophages
Shin et al., Int Immunopharmacol 2010 : Sulfuretin isolated from heartwood of Rhus verniciflua inhibits LPS induced inducible nitric oxide synthase , cyclooxygenase-2, and pro-inflammatory cytokines expression via the down-regulation of NF-kappaB in RAW 264.7 murine macrophage cells
Wu et al., J Sci Food Agric 2010 (Inflammation) : Ethanolic extracts from both stem and leaf of C. sativum ( CSEE ) significantly decreased LPS induced nitric oxide and prostaglandin E ( 2 ) production as well as inducible nitric oxide synthase , cyclooxygenase-2, and pro-interleukin-1beta expression
Matsui et al., Anesth Analg 2010 : Spinal microglia isolated from Sprague-Dawley neonatal rats were cultured with lipopolysaccharide (LPS) or substance P ( SP ) alone, with LPS in combination with SP, and with LPS in the presence of each inhibitor of cyclooxygenase (COX), NO synthase 2 (NOS2) or p38 mitogen activated protein kinase ( p38 ), or minocycline for 24 hours and 48 hours
Hseu et al., Food Chem Toxicol 2010 : In an earlier study, we found that Antrodia camphorata inhibited the production of lipopolysaccharide (LPS) induced cytokines, inducible nitric oxide synthase , and cyclooxygenase-2 by blocking nuclear factor-kappaB (NF-kappaB) activation in cultured RAW 264.7 macrophages
Hsieh et al., J Biol Chem 2011 : Andrographolide was shown to suppress LPS/IFN-? induced inducible nitric-oxide synthase and matrix metalloprotease 9 expression in rat VSMCs. Andrographolide also inhibited LPS/IFN-? induced p65 nuclear translocation, DNA binding activity, p65 Ser ( 536 ) phosphorylation, and NF-?B reporter activity
Valente et al., Neurobiol Aging 2012 (Amyotrophic Lateral Sclerosis...) : In this study we demonstrate that the expression of nitric oxide ( NO ) synthase-2 ( NOS2 ), and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) with interferon-? is higher in microglial enriched cultures from G93A-SOD1 mice, an ALS animal model, than from wild type mice
Mogilenko et al., FASEB J 2012 : We have shown that endogenous ApoA-I stabilizes ABCA1, moreover, down-regulation of ApoA-I by siRNA results in an increase of Toll-like receptor 4 (TLR4) mRNA and membrane surface protein expression, as well as an enhancement of bacterial lipopolysaccharide (LPS) induced expression of tumor necrosis factor-a (TNF-a), interleukin 1ß (IL-1ß), and inducible nitric oxide synthase ( NOS2 ) genes in human macrophages
Chinta et al., Parkinson's disease 2012 : DHB significantly attenuated LPS mediated induction of nitric oxide synthase and pro-inflammatory cytokines in murine BV2 microglial cells in vitro in conjunction with reduced ROS production and activation of NF?B and MAPK pathways possibly due to up-regulation of HO-1 levels
Patruno et al., Biochim Biophys Acta 2012 (Inflammation) : These results suggest that LPS regulates the opposite NOS expression in H9c2 cells by modifying the redox state of these cells responsible for the NF-kB nuclear translocation via NIK-IKKa/ß-IkBa, simultaneous to the inactivation of the PI3K/Akt pathway
Yang et al., Mol Cell Biochem 2013 (Inflammation) : Treatment with AH inhibited lipopolysaccharide (LPS) induced interleukin-6, IL-1ß, inducible nitric oxide synthase , and cyclooxygenase-2 expression and nitric oxide production
Bai et al., J Surg Res 2013 (Acute Lung Injury...) : In addition, shikonin pretreatment significantly suppressed LPS induced activation of cyclooxygenase 2 and inducible nitric oxide synthase and the nuclear factor ?B DNA binding activity in lung tissues
Ro et al., Transplantation 2012 : Both polyriboinosinic polyribocytidylic acid and lipopolysaccharide (LPS) stimulation induced the mRNA expression of regulated and normal T cell expressed and secreted, interferon-?-inducible protein-10, monocyte chemotactic protein-1, interleukin-8, and inducible nitric oxide synthase in murine islets, whereas the induction was attenuated in TRIF-KO, interferon-ß promoter stimulator-1-KO, and TLR4-KO mice
Murakami et al., Biofactors 2013 (Colitis...) : Both CUR and ATM inhibited lipopolysaccharide (LPS) induced expression of inducible forms of both nitric oxide synthase and cyclooxygenase ( iNOS and COX-2, respectively )
Sinha et al., Chem Res Toxicol 2013 (Neoplasms) : LPS mediated induction of nitric oxide synthase in murine macrophages resulted in VP-16 resistance compared to Raw cells
Li et al., Mol Med Report 2013 (Acute Lung Injury...) : The upregulation of matrix metalloproteinase-9, interleukin (IL)-1ß, IL-6 and inducible nitric oxide synthase was induced by LPS in the mouse model of sepsis and the TC-1 cell line, and resveratrol suppressed the overexpression of these proinflammatory molecules in a dose-dependent manner
McMillian et al., Biochem Biophys Res Commun 1995 : LPS induced nitric oxide synthase (NOS) in microglia, increased the media level of the NO metabolite nitrite, and the NOS inhibitor Ng-nitro-L-arginine methylester ( NAME ) protected the ChAT+ neurons from LPS
Baydoun et al., Br J Pharmacol 1993 : 1. Effects of dexamethasone on induction of nitric oxide ( NO ) synthase and L-arginine transport by lipopolysaccharide (LPS) were examined in a murine cultured macrophage cell line J774
Fujihara et al., J Immunol 1994 : Thus, PKC could be a part of the signal transduction apparatus involved in LPS induced inducible nitric oxide synthase gene activation
Chesrown et al., Biochem Biophys Res Commun 1994 : Regulation of inducible nitric oxide synthase mRNA levels by LPS , INF-gamma, TGF-beta, and IL-10 in murine macrophage cell lines and rat peritoneal macrophages
Yan et al., J Immunol 1994 : In addition, NOS activity was not induced in PMNs by LPS , IL-1 beta, or IFN-gamma
Sparrow et al., Exp Eye Res 1994 : Conversely, when transforming growth factor-beta was present in the culture medium, gamma-interferon-LPS induced expression of nitric oxide synthase and NO release were reduced
Paul et al., Br J Pharmacol 1995 : 1. In RAW 264.7 macrophages, lipopolysaccharide (LPS) and gamma-interferon ( IFN gamma ) alone or in combination stimulated the induction of nitric oxide synthase ( iNOS ) activity and increased the expression of the 130 kDa isoform of NOS ... 2. LPS induced NOS activity was reduced by incubation with CD14 neutralising antibodies and abolished in macrophages deprived of serum ... 4. The protein kinase C inhibitor, Ro-318220, abolished both LPS- and IFN gamma stimulated protein kinase C activity and the induction of NOS activity ... 8. These results suggest the involvement of protein kinase C, tyrosine kinase and poly-ADP ribosylation pathways in the regulation of the induction of nitric oxide synthase in RAW 264.7 macrophages by LPS and IFN gamma
Park et al., J Neurosci Res 1994 (Glioma) : LPS induction of NOS in C6 cells was evidenced by a small amount of nitrite accumulation as compared with cells exposed to IL-1 beta/IFN-gamma, but the maximal NOS activity achieved ( as revealed by cGMP formation ) was the same ... The NOS activity induced by LPS in C6 cells was maximal at 4 to 8 hr and then rapidly decreased, while NOS activity induced by IL-1 beta/IFN-gamma slowly decreased after 4 hr
McKenna et al., Shock 1994 : LPS and beta-PDB induced a sustained translocation of PKC activity from the cytosol to the membrane, an increased protein synthesis dependent expression of nitric oxide synthase (NOS) activity, and an impaired contractility that could be partially reversed by treatment with the NOS inhibitor N omega-nitro-L-arginine methyl ester ... These data indicate that PKC plays a role as an intracellular mediator of LPS induced NOS activity and vascular suppression
Hamilton et al., J Clin Invest 1995 : The cooperative effects of IFN gamma and LPS on the expression of the inducible nitric oxide synthase gene were suppressed by oxidized LDL while the antagonistic effect of IFN gamma on LPS induced expression of the TNF receptor type II mRNA was not altered
Parker et al., Shock 1994 (Toxemia) : Since L-NAME unmasked a vasoconstrictor action of the endogenous purinoceptor agonist ADP, pharmacologic agents that inhibit NOS may exacerbate LPS induced inhibition of endothelial NOS ; this series of events could lead to diminution of vasodilator reserves and perhaps to augmentation of platelet aggregation during Gram negative sepsis
Wang et al., Biochem Biophys Res Commun 1995 : In view of studies showing that not only nitric oxide synthase (NOS) activity but arginase activity is induced in rodent macrophages by lipopolysaccharide (LPS) , the objective of this study was to investigate the co-induction of these two enzymes and to ascertain whether common mechanisms are involved
Loegering et al., Life Sci 1995 : The present study evaluated the ability of the antioxidant, diethyldithiocarbamate ( DDTC ), to attenuate the LPS stimulated induction of NOS in cultured vascular smooth muscle cells ( VSMC ) and the depression of in vitro vascular reactivity caused by LPS administration to rats ... These results suggest that DDTC can attenuate the LPS stimulated induction of NOS in vascular smooth muscle and may thereby ameliorate the impairment of vascular reactivity
Nishiya et al., FEBS Lett 1995 (Glioma) : Herbimycin A, a potent tyrosine kinase inhibitor, suppressed nitric oxide synthase (NOS) induced by lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) in C6 glial cells
Wood et al., Biochem Biophys Res Commun 1993 : NOS gene expression in hepatocytes is dependent upon bacterial lipopolysaccharide (LPS) and cytokine treatment
Feinstein et al., J Neurochem 1993 : In these cells, the presence of norepinephrine ( NE ) caused a dose dependent inhibition of the LPS induction of NOS activity, with an IC50 value of 100 nM and significant suppression at 100 pM ... In contrast to astroglial cultures, LPS induction of NOS activity in RAW 264.7 macrophage cells was not affected by NE or dibutyryl cyclic AMP
Goureau et al., Proc Natl Acad Sci U S A 1993 : Transforming growth factor beta 1 slightly increases the production of nitrite, an oxidation product of NO, induced by LPS plus IFN-gamma, whereas acidic and basic FGFs markedly inhibit the nitrite release due to LPS/IFN-gamma in a concentration dependent manner, and epidermal growth factor did not modify LPS/IFN-gamma induced NOS activity ... Results with heparin, suramin, and tyrphostin suggest involvement of the high-affinity receptor for FGF in its inhibition of LPS/IFN-gamma stimulated NOS activity
Mitchell et al., Br J Pharmacol 1993 : The spleen, lung, mesentery and liver had the highest amounts of LPS induced NOS activity
Szabó et al., J Pharmacol Exp Ther 1993 : Thus, nifedipine inhibits the induction of NOS in response to LPS in cultured cells in vitro and in the anesthetized rat
Gilbert et al., J Cell Physiol 1993 : LPS is a potent inducer of mac-NOS in Swiss 3T3 cells but can not induce TIS10/PGS-2
Lowenstein et al., Proc Natl Acad Sci U S A 1993 : Region I contains LPS related responsive elements, including a binding site for nuclear factor interleukin 6 ( NF-IL6 ) and the kappa B binding site for NF-kappa B, suggesting that this region regulates LPS induced expression of the mac-NOS gene ... Region II contains motifs for binding IFN related transcription factors and thus probably is responsible for IFN mediated regulation of LPS induced mac-NOS
Thiemermann et al., Br J Pharmacol 1993 (Shock, Septic) : TNFab pretreatment significantly attenuated this induction of NOS in response to LPS by 37 +/- 6 % ( n = 5 ; P < 0.05 ) .5
McKenna et al., Am J Physiol 1995 : LPS ( 100 ng/ml ) stimulated myocyte PKC activity, inducible NOS (iNOS) expression, and NOS activity in a time- and protein synthesis dependent fashion ... These findings suggest that PKC is a significant intracellular mediator for the effects of LPS on cardiac cell NOS activity and contractile function
Cendan et al., J Surg Res 1996 (Mammary Neoplasms, Animal) : Confluent EMT-6 murine breast cancer cells were incubated with LPS ( 10 microgram/ml ) and IFN ( 50 units/ml ) in the presence or absence of the NOS inhibitors, L-NAME ( 2 mM ) or AG ( 1 mM ), and arginine transport ( using L- [ 3H ] arginine ) and NO production ( the stable end-product nitrite was assayed using the Greiss reagent ) were measured at various time points
Mustafa et al., Hepatology 1996 (Shock, Septic) : The current study indicates that exogenous PAF contributes to the induction of nitric oxide synthase by LPS in cultured rat Kupffer cells
Cirino et al., Br J Pharmacol 1996 : 1. The effects of novel nitric oxide releasing nonsteroidal anti-inflammatory compounds ( NO-NSAIDs ) on induction of nitric oxide ( NO ) synthase by bacterial lipopolysaccharide (LPS) were examined in a murine cultured macrophage cell line, J774
Ruetten et al., Biochem Biophys Res Commun 1996 : This study elucidates the effects of the NOS inhibitors aminoethyl-isothiourea ( AE-ITU ), aminoguanidine ( AG ), NG-methyl-L-arginine ( L-NMMA ) or N omega-Nitro-L-arginine methyl ester ( L-NAME ) on the expression of iNOS protein lipopolysaccharide (LPS) in macrophages and the rat ( lung homogenates )
Coffey et al., Biochem Pharmacol 1996 : Inhibition was greatest if THC was added 1-4 hr before induction of nitric oxide synthase (NOS) by LPS and IFN-gamma, and declined with time after addition of the inducing agents
Romero et al., Am J Physiol 1996 : Although IL-1 beta and TNF-alpha are themselves capable of inducing NO synthase (NOS) in glia, the specific factors mediating LPS induction of NOS in brain have not been identified ... To determine whether LPS induction of NOS in brain cells is mediated by IL-1 or TNF-alpha, acting alone or in concert, the effects of IL-1-receptor antagonist (IL-1Ra) and of TNF-soluble receptor ( TNFsRp55 ), presented individually and in combination, on LPS induced NOS activity were tested ... The results indicate that LPS induction of NOS activity in brain cells is mediated in part by both IL-1 beta and TNF-alpha
Kitamura et al., J Neurosci Res 1996 : To clarify the properties of an inducible type of nitric oxide synthase ( i-NOS ) in the brain, we examined whether lipopolysaccharide (LPS) induces NOS in glial cells cultured from neonatal rats
Weisbrodt et al., Am J Physiol 1996 : This study was designed to determine if an increase in nitric oxide synthase (NOS) activity induced by lipopolysaccharide (LPS) is associated with increases in NOS II protein and mRNA abundance and with altered ileal longitudinal muscle contractility ... These data confirm the reported effects of LPS on intestinal NOS activity and indicate that it can be attributed, at least in part, to an increase in NOS II mRNA and protein abundance
Iguchi et al., J Appl Toxicol 1996 : Thus, the three kinds of asbestos used seemed to interfere with LPS in inducing NOS and to decrease subsequently the synthesis of NO2-, but not to affect the synthesis of NO2- by LPS induced NOS
Eason et al., Arch Int Pharmacodyn Ther 1995 : These results provide strong evidence for the involvement of tyrosine kinases in the induction of nitric oxide synthase by LPS and IFN-gamma in J774 macrophages
Sorrells et al., Arch Surg 1996 : In addition, LPS upregulates inducible nitric oxide synthase expression in the intestinal epithelium-a phenomenon that can either enhance microbial killing, or alternatively, promote BT by impairing the gut barrier
Muller et al., Br J Pharmacol 1996 : 5. These results provide evidence that, within vascular tissue, NO generated from L-Arg by LPS induced NOS activity can be stored as protein bound DNIC in non-endothelial cells
Noda et al., J Biochem 1997 : However, it revealed two apparent Kms for beta-NADPH, a co-factor of NOS ; one was about 0.4 microM, which was common to these two iNOSs, and the other was about 1.5 and 25 microM for LPS induced NOS and LPS + IFN-gamma induced NOS, respectively
Sekkaï et al., Arch Biochem Biophys 1997 : Indoleamine 2,3-dioxygenase (IDO) and nitric oxide synthase (NOS) type II are induced in macrophages by interferon (IFN)-gamma and lipopolysaccharide (LPS)
Martin et al., Infect Immun 1997 : In gram negative septic shock, lipopolysaccharide (LPS) induces nitric oxide ( NO ) synthase , which contributes to the vascular hypotension and hyporeactivity to vasoconstrictors
Salkowski et al., Infect Immun 1997 : We compared the ability of LPS and MPL to induce interleukin-10 (IL-10), IL-12 p35, IL-12 p40, gamma interferon ( IFN-gamma ), glucocorticoid receptor ( GR ), IL-1 receptor antagonist (IL-1ra), and inducible nitric oxide synthase mRNA expression in murine peritoneal macrophages
Goureau et al., Biochem Biophys Res Commun 1997 : Since the induction of nitric oxide synthase (NOS) by lipopolysaccharide (LPS) has been suggested to be partially dependent of the synthesis of tumor necrosis factor alpha (TNF alpha), we have investigated in vitro the production of NO in retinal cells from mice deficient in Lymphotoxin alpha (LT alpha)/TNF alpha
Schwacha et al., J Leukoc Biol 1998 (Burns) : Inhibition of nitric oxide synthase activity with NG-monomethyl-L-arginine restored ConA responses but not LPS responses
Sastre et al., Biochem J 1998 : As expected, LPS dose-dependently stimulated the inducible nitric oxide synthase activity ( iNOS )
Tawara et al., J Neurosci Res 1998 (Glioma) : In addition, pretreatment of the cells with 100 nM dexamethasone for 24 hr significantly suppressed LPS induced inducible nitric oxide synthase ( iNOS ; type II NOS, NOS-II ) protein expression
Noda et al., Biol Pharm Bull 1998 : Defect in the induction of nitric oxide synthase by lipopolysaccharide (LPS) in an LPS-resistant mutant of a murine macrophage-like cell line, J774.1
Chang et al., Biochem Biophys Res Commun 1998 : Consistent with this finding, Northern blot analysis indicated that 25-OH-cholesterol potentiated the LPS induced nitric oxide synthase RNA levels
McKinney et al., J Leukoc Biol 1998 : Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines : role of TNF-alpha
Gao et al., J Immunol 1998 : We have examined the role of Stat1alpha in the induction by LPS of the mouse inducible nitric oxide synthase ( EC 1.14.13.39 ) gene ... Collectively, these results show that LPS induced IFN-alphabeta production, Stat1alpha activation, and nitrite accumulation closely parallel one another, suggesting that indirect activation of transcription factor Stat1alpha by IFN-alphabeta is a critical determinant of LPS mediated inducible nitric oxide synthase gene expression
Closs et al., FASEB J 1998 (Diarrhea...) : LPS induces nitric oxide synthase II ( NOS II, inducible NOS ) in various types of cells
Lysle et al., J Pharmacol Exp Ther 1999 : In the present study, we tested the hypothesis that lipopolysaccharide (LPS) induced expression of nitric oxide synthase ( iNOS ) by splenocytes is modulated through the activation of endogenous opioids in the central nervous system