◀ Back to TNF
IFNB1 — TNF
Pathways - manually collected, often from reviews:
-
WikiPathways EBV LMP1 signaling:
NFKB1/RELA
→
Complex of CXCL8-IFNB1-CCL20-TNF-CCL5
(activation)
Text-mined interactions from Literome
Gayo et al., Neurology 1999
(Multiple Sclerosis) :
After 1 year of therapy,
IFNbeta-1b restored the normal production of
TNFalpha , whereas therapy did not restore IFNgamma secretion to control values
Lou et al., Lab Invest 1999
(Multiple Sclerosis) :
Furthermore
IFN-beta did not modulate the expression of adhesion molecules on either stimulated leukocytes or activated HB-MVEC, but partially
reduced TNF and interleukin-1 production from stimulated leukocytes during coculture with HB-MVEC
Van Weyenbergh et al., Immunol Lett 2001
:
The differential effect of IFN-beta and TGF-b on IL-12 bioactivity was most pronounced upon IFN-gamma synthesis, since
IFN-beta induced only marginal amounts of IL-10 and IL-12 and TGF-beta diminished constitutive IL-10 production, while neither had a significant effect on
TNF-alpha production
Jovasevic et al., J Immunol 2001
(Plasmacytoma) :
Thus, the IFN-beta gene is an early response gene that is activated in response to L-PAM via a pathway that involves reactive oxygen species, and
IFN-beta in turn
plays an important role in L-PAM induced
TNF-alpha up-regulation
Iarlori et al., J Neuroimmunol 2002
(Multiple Sclerosis...) :
IFNbeta-1b , in vitro,
increases MCP-1,
TNFalpha and IFNgamma spontaneous production in all patients
Hua et al., J Neurochem 2002
:
In primary cultures of human astrocytes, we determined the
effects of
IFN-beta on astrocyte cytokine
[tumor necrosis factor-alpha ( TNF-alpha ) and interleukin (IL)-6 ] and inducible nitric oxide synthase (iNOS) expression by ribonuclease protection assay and ELISA
Jirillo et al., J Endotoxin Res 2002
(Toxemia) :
An exaggerated production of TNF-alpha has been reported in murine viral infections, in which mice become sensitized to low amounts of LPS and both interferon (IFN)-gamma and
IFN-alpha/beta are
involved in the macrophage induced release of
TNF-alpha
Pandita et al., FEBS Lett 1992
:
Furthermore, by using antibodies specific to each type of receptor, we demonstrate that both
TNF receptors are equally
inducible by IFN-alpha,
IFN-beta and IFN-gamma
Tliba et al., J Biol Chem 2003
(Inflammation) :
Using neutralizing antibodies to IFNbeta and TNFalpha receptor 1, we show that
TNFalpha induced secretion of
IFNbeta mediated gamma activated site dependent gene expression via activation of TNFalpha receptor 1
Molnarfi et al., J Neuroimmunol 2004
:
Furthermore, we recently demonstrated that
IFNbeta inhibits the production of IL-1beta and
tumor necrosis factor-alpha (TNF) in human monocytes activated by cellular contact with stimulated T cells, a mechanism which we suspected of playing an important part in the pathogenesis of chronic inflammatory diseases including MS ... Here we compare modulatory
effects of
IFNbeta on the production of proinflammatory cytokines ( IL-1beta, IL-1alpha,
TNF , and IL-6 ) and IL-1Ra in human monocytes stimulated by lipopolysaccharides (LPS) and isolated plasma membranes of stimulated T cells ( msHUT ), which are likely to reflect monocyte activation in acute and chronic inflammation, respectively ...
IFNbeta inhibited the expression ( mRNA ) and production ( protein ) of IL-1beta and
TNF , while enhancing those of IL-1Ra in monocytes activated by msHUT
Arbour et al., Mult Scler 2005
(Multiple Sclerosis) :
We measured the in vivo and in vitro
effects of
interferon (IFN)beta and glatiramer acetate ( GA ) on the expression of the regulatory molecule,
tumor necrosis factor related apoptosis inducing ligand ( TRAIL ), in patients with multiple sclerosis (MS)
Tsung et al., Am J Physiol Gastrointest Liver Physiol 2006
(Reperfusion Injury) :
Whereas IFN-gamma and
IFN-beta were strong inducers of IRF-1 mRNA ( > 10-fold ) in a time- and dose dependent manner,
TNF-alpha and IL-1beta also
induced IRF-1 mRNA to a lesser extent ( 2- to 3-fold )
Ben-Hur et al., J Neuroimmunol 2006
:
IFN-beta suppressed the
TNF-alpha induced levels of secreted MMP-9 and MMP-2, while enhancing the expression of TIMP-1 and TIMP-2 mRNA
Punturieri et al., J Immunol 2006
:
Surprisingly, combined stimulation by OMPs and
IFN-beta also markedly
enhanced TNF-alpha release by murine AMphi ... AMphi derived from STAT1-deficient mice did not demonstrate increased production of
TNF-alpha in
response to PCP plus
IFN-beta
Van Damme et al., J Invest Dermatol 1990
:
This study focuses on
interferon-beta (IFN-beta) , interleukin-6 (IL-6), and interleukin-8 (IL-8) production by fibroblasts and epithelial cells in
response to interleukin-1 (IL-1) and
tumor necrosis factor-alpha (TNF-alpha)
Bachmann et al., Int J Cancer 2007
(Cardiovirus Infections...) :
However, regarding cancer as a non-linear system, which may, even in the absence of an apparent selection pressure, fluctuate between different `` metastable '' phenotypes, we demonstrate that
TNF-alpha mediated
IFN-beta induction is not irreversibly disturbed in all cells
Jin et al., Brain Res 2007
:
Although
IFN-beta enhanced the production of
tumor necrosis factor (TNF)-alpha , interleukin (IL)-1beta, and nitric oxide ( NO ) by activated microglia, these molecules did not directly induce neurotoxicity in cultured cortical neurons
Feduchi et al., Virology 1991
:
Antibodies against IFN beta block this synergism, implying a
role of
IFN beta in the antiviral activity of
TNF plus IFN gamma ... Our results are in accordance with the idea that
TNF induces
IFN beta 1 and that both cytokines must be present in the culture medium to synergize with IFN gamma in order to inhibit HSV-1 replication
Wang et al., J Immunol 2008
(Salmonella Infections, Animal) :
LPS- and
IFN-beta induced
TNF-alpha are suppressed in RIG-I-deficient mouse embryo fibroblasts ( rig ( -/ ) ( - ) )
Lus et al., J Interferon Cytokine Res 2009
(Multiple Sclerosis...) :
To examine the
effect of high-dose
interferon (IFN)-beta1a [ 44 microg administered subcutaneously ( sc ) 3 times weekly ( tiw ) ] on
tumor necrosis factor-alpha (TNF-alpha) and insulin-like growth factor-1 (IGF-1) levels in patients with relapsing remitting multiple sclerosis ( RRMS ), and any correlation with clinical and magnetic resonance imaging ( MRI ) data
Ahrens et al., J Gen Virol 1990
:
We conclude that the
TNF-alpha induction of antiviral activity and UCRP in cells is
dependent upon the presence of constitutive low levels of
IFN-beta in the responding cells
Ito et al., Lymphokine Res 1987
:
This suggested the
induction of
IFN-beta by
TNF
Gessani et al., J Biol Regul Homeost Agents 1988
:
TNF induced transcription of
IFN-beta 2 in resistant variants, indicating that this cytokine does not contribute to the antiviral activity of TNF
Ruggiero et al., Antiviral Res 1989
:
The in vitro antiviral activity of
tumor necrosis factor (TNF) in WISH cells is
mediated by
IFN-beta induction
Reis et al., J Biol Chem 1989
:
Our results support the conclusion that autocrine
IFN-beta is secreted by untreated normal fibroblasts and that
TNF can
enhance the production of autocrine IFN-beta by increasing the level of IFN-beta mRNA
Hughes et al., Antiviral Res 1988
:
Synergy of antiviral actions of TNF and IFN-gamma : evidence for a major role of
TNF induced
IFN-beta
Kohase et al., Cell 1986
:
We also show that antiserum to IFN-beta enhanced the mitogenic effect of TNF in confluent, serum starved human fibroblasts, suggesting that
induction of
IFN-beta by
TNF represents a physiological negative feedback mechanism regulating cell proliferation
Tsujimoto et al., J Immunol 1986
:
In HeLa cells, IFN-alpha and
IFN-beta increased
125I-TNF binding, whereas in HT-29 cells these two IFN either slightly decreased or had no effect on 125I-TNF binding ... Both IFN-alpha and
IFN-beta exerted an antagonistic effect on IFN-gamma induced stimulation of TNF receptor expression in HT-29 cells, but did not
inhibit TNF receptor induction by IFN-gamma in HeLa cells ... Despite the inhibitory
effect of
IFN-beta on the IFN-gamma induced stimulation of
TNF receptor expression, IFN-beta did not inhibit the synergistic enhancement of TNF cytotoxicity by IFN-gamma in HT-29 cells ... The dissociation between the
effects of
IFN-beta on
TNF receptor expression and on the cytotoxic activity of TNF in HT-29 cells suggests that TNF receptor modulation is not a major mechanism of synergism between IFN and TNF
Sehgal et al., Proc Natl Acad Sci U S A 1987
:
The
enhancement of
IFN-beta 2 gene expression by diC8, interleukin 1, or
tumor necrosis factor was not prevented by H8, a preferential inhibitor of cAMP- and cGMP dependent protein kinases, but was blocked by H7, an inhibitor of protein kinase C as well as of cyclic nucleotide dependent protein kinases
May et al., J Biol Chem 1988
:
`` Uninduced '' human FS-4 fibroblasts as well as those
induced with interleukin-1 alpha,
tumor necrosis factor , or bacterial lipopolysaccharide secrete at least five forms of
IFN-beta 2 of apparent molecular mass in the range from 23 to 30 kDa which can be resolved by polyacrylamide gel electrophoresis under denaturing and reducing conditions
Kohase et al., J Interferon Res 1988
:
In contrast to IL1,
TNF did not
inhibit IFN-beta synthesis, nor did it interfere with the antiviral action of IFN-beta
May et al., Proc Natl Acad Sci U S A 1986
:
Polyclonal and monoclonal anti-IFN-beta antibodies inhibit the increase in class I HLA gene expression ( HLA-B7 mRNA ) in TNF treated FS-4 cells suggesting that
TNF induced
IFN-beta 2 mediates the enhancing effect of TNF on HLA gene expression in human fibroblasts
Horikoshi et al., FEBS Lett 1995
:
Interferon-beta (IFN-beta) at concentrations of 10, 100, and 1000 IU/ml in the
presence of
tumor necrosis factor-alpha (TNF-alpha) significantly increased the ICAM-1 expression of fibroblasts in a dose dependent manner
Arnason et al., J Neural Transm Suppl 1997
(Demyelinating Diseases...) :
IFN beta-1b also
inhibits release of lymphotoxin,
tumor necrosis factor , and interferon gamma, at least in vitro
Coclet-Ninin et al., Eur Cytokine Netw 1997
:
Interferon-beta not only
inhibits interleukin-1beta and
tumor necrosis factor-alpha but stimulates interleukin-1 receptor antagonist production in human peripheral blood mononuclear cells
Weber et al., Ann Neurol 1998
(Multiple Sclerosis) :
In vitro studies with myelin basic protein (MBP)-specific T-cell lines revealed a synergistic suppressive
effect of
IFN-beta1b and the phosphodiesterase inhibitor pentoxifylline ( PTX ) on proliferation and the production of
tumor necrosis factor-alpha (TNF-alpha) , lymphotoxin ( LT ), and interferon-gamma (IFN-gamma)