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IL10 — SYK
Text-mined interactions from Literome
Slack et al., Eur J Immunol 2007
:
Syk dependent ERK activation
regulates IL-2 and
IL-10 production by DC stimulated with zymosan
Gow et al., J Infect Dis 2007
(Candidiasis...) :
Dectin-1 induced cytokine production through the following 2 pathways :
Syk dependent production of the T-helper ( Th ) 2-type anti-inflammatory cytokine
interleukin-10 and Toll-like receptor-Myd88 dependent stimulation of monocyte derived proinflammatory cytokines, such as tumor necrosis factor-alpha
Hatton et al., J Biol Chem 2011
(Epstein-Barr Virus Infections...) :
Syk inhibition also
reduces autocrine
IL-10 production
Hatton et al., PloS one 2012
(Lymphoma, B-Cell) :
Using small molecule inhibition and siRNA strategies in human B cell lines expressing a chimeric, signaling-inducible LMP1 protein, nerve growth factor receptor (NGFR)-LMP1, we show that NGFR-LMP1 utilizes
Syk to activate PI3K/Akt signaling and
induce IL-10 production