◀ Back to CASP9
CASP2 — CASP9
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Robertson et al., Crit Rev Toxicol 2000
:
Caspase-9 can signal downstream and
activate pro-caspase-3 and -7
Viswanath et al., J Neurosci 2001
(Disease Models, Animal...) :
Caspase-9 activation
results in downstream
caspase-8 activation and bid cleavage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induced Parkinson 's disease ...
Caspase-9 inhibition
prevented the activation of both caspase-3 and
caspase-8 and also inhibited Bid cleavage, but not cytochrome c release
Robertson et al., Toxicology 2002
(Necrosis) :
Caspase-9 can signal downstream and
activate pro-caspase-3 and -7
Justo et al., J Am Soc Nephrol 2003
:
Caspase-2 , caspase-3, and caspase-9 were activated, and specific
caspase inhibitor
prevented apoptosis and increased long-term survival
Fu et al., Cardiovasc Res 2004
:
Caspase-2 , -3, -6 and -9 were activated during apoptosis and
caspase-2 inhibitor ( Z-VDVAD-FMK ) and caspase-3 inhibitor ( Z-DEVD-FMK ) significantly
attenuated the apoptosis
Cuello et al., Cell Death Differ 2004
:
Caspase-9 may further
activate caspase-8 , generating an amplification loop
Perchellet et al., Anticancer Drugs 2004
:
Caspase-2 and -8 may both act upstream of mitochondria to promote Cyt c release, but
caspase-2 is already maximally
activated 6 h after 4 microM DAU or TT13 treatments, whereas DAU- or TT-induced caspase-8 and -9 activities peak at 9 h. Pre-treatments with 15 microM of the caspase-2 inhibitor benzyloxycarbonyl ( z ) -Val-Asp-Val-Ala-Asp ( VDVAD ) -fluoromethyl ketone ( fmk ) totally block DAU- and TT13 induced caspase-2, -8 and -9 activities, whereas pre-treatments with 15 microM of the caspase-8 inhibitor z-Ile-Glu-Thr-Asp ( IETD ) -fmk prevent DAU and TT13 from inducing caspase-8 activities without affecting their caspase-2- and -9-inducing activities, suggesting that the induction of apical caspase-2 activity by these drugs may be a critical upstream event required for the activation of other downstream caspases, including caspase-9 and the mitochondrial amplification loop through caspase-8
Martin et al., J Biol Chem 2005
:
Caspase-9 cleaves and
activates effector caspases, predominantly
caspase-3 , resulting in the demise of the cell
Ho et al., FEBS J 2005
:
Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins ( IAPs ) and can
activate caspase-7
Lombard et al., Leuk Res 2005
(Leukemia, T-Cell) :
Caspase-2 inhibitor
blocked THC induced
caspase-3 in wild-type Jurkat cells but not loss of Deltapsi ( m )
Lang-Rollin et al., Apoptosis 2005
:
Caspase 9 and 3 are processed, cytochrome c is released from the mitochondria and a dominant negative form of
caspase 9
prevents death
Daher et al., Exp Dermatol 2006
:
Caspase-9-DN and zLEHD-fmk both
suppressed caspase-9 , -3, and -8 activity after UVB exposure, as well as proteolytic processing of procaspase-3 into its active form, DNA fragmentation factor 45 cleavage, and internucleosomal DNA fragmentation
Uchiyama et al., Infect Immun 2007
(Necrosis) :
Caspase-9 activation was also detected in H37Rv infected cells, but H37Ra never
induced such
caspase-9 activation
Zhao et al., Tohoku J Exp Med 2008
(Myocardial Infarction...) :
Caspase-9 cleaves and
activates caspase-3
Tang et al., Oncol Rep 2009
(Adenocarcinoma...) :
Caspase-9 and -3 inhibitors almost completely
suppressed HCT induced
caspase-9 and -3 activities
Shi et al., Toxicol Lett 2010
:
Caspase 9 inhibition
blocked the TNP induced activation of
caspase 3 significantly
Ohsawa et al., Proc Natl Acad Sci U S A 2010
:
Maturation of the olfactory sensory neurons by
Apaf-1/caspase-9 mediated
caspase activity ... Here, we provide unique evidence that
Apaf-1/caspase-9 mediated
caspase signaling regulates the development of olfactory sensory neurons ( OSNs ), which includes axonal projection, synapse formation, and maturation of these neurons
Liu et al., PloS one 2012
:
Caspase-9 inhibitor could
inhibit activation of
pro-caspase-3 , and the inhibition of the function of Apaf-1 with FSBA blocked apoptosis, hinting that Apaf-1 could be involved in Sl-1 cell apoptosis induced by AfMNPV
Stefanis et al., J Neurochem 1997
:
We have shown previously that selective
cysteine aspartase ( caspase ) inhibitors protect PC12 cells and sympathetic neurons from such death, and that the caspase
Nedd-2 is
required for this type of death to occur