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PARP1 — SOX2

Text-mined interactions from Literome

Gao et al., J Biol Chem 2009 : When PARP1 activity is inhibited or absent, poly ( ADP-ribosyl ) ation of Sox2 decreases and association of Sox2 with FGF4 enhancers increases , accompanied by an elevated level of Sox2 proteins and reduced expression of FGF4
Lai et al., Proc Natl Acad Sci U S A 2012 : The results presented below demonstrate that Parp1 regulates Sox2 protein activity ... In response to fibroblast growth factor ( FGF ) /extracellular signal regulated kinase ( ERK ) signaling, Parp1 auto-poly ADP-ribosylation enhances Sox2-Parp1 interactions, and this complex inhibits Sox2 binding to octamer binding transcription factor 4 ( Oct4 ) /Sox2 enhancers ... In addition, we demonstrate that regulation of Sox2 activity by Parp1 is critical for efficient generation of induced pluripotent stem cells