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CTLA4 — PARP1

Text-mined interactions from Literome

Dillon et al., Mol Cell Biol 2005 : Regulation of the small GTPase Rap1 and extracellular signal regulated kinases by the costimulatory molecule CTLA-4 ... Together, CD3 and CTLA-4 activate Rap1 in a sustained manner ... We demonstrate that CTLA-4 activates Rap1 , and we propose that intracellular signals from CTLA-4 antagonize CD28, at least in part, at the level of Rap1
Schneider et al., Proc Natl Acad Sci U S A 2005 (Tissue Adhesions) : CTLA-4 up-regulated adhesion was mediated by regulator for cell adhesion and polarization type 1 ( Rap-1 ) as shown by anti-CTLA-4 induced Rap-1 activation as well as Rap-1-N17 blockade and Rap-1-V12 mimicry of adhesion/clustering