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CD4 — CLTA
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Arf1 pathway:
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP complex (CD4-CLTA-COPA-CLTB-ARF1)
→
coatomer protein complex/ARF1/GTP complex (CLTA-COPA-CLTB-ARF1)
(modification, collaborate)
-
NCI Pathway Database Arf1 pathway:
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex/Coatomer protein complex/ARF1/GTP complex (CD4-CLTA-COPA-CLTB-ARF1)
→
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex complex (CD4)
(modification, collaborate)
-
NCI Pathway Database Arf1 pathway:
coatomer protein complex/ARF1/GTP complex (CLTA-COPA-CLTB-ARF1)
→
CD4/HIV Nef/AP2/vacuolar proton-transporting V-type ATPase complex complex (CD4)
(modification, collaborate)
Text-mined interactions from Literome
Gattinoni et al., Blood 2006
(Autoimmune Diseases...) :
These results indicated that CD8 ( + )
CLTA-4 ( -/- ) T-cell mediated autoimmunity and tumor immunity
required CD4 ( + ) T cells in which the function was dysregulated by the absence of CTLA-4 mediated negative costimulation
Hokey et al., J Med Primatol 2008
:
CLTA-4 blockade
enhanced CD4 ( + ) and CD8 ( + ) central memory ( CD28 ( hi ), CD95 ( hi ) ) T-cell responses as well as a short lived CD8 ( + ) effector ( CD28 ( lo ), CD95 ( hi ) ) T-cell response