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FOS — HOXD13

Text-mined interactions from Literome

Mo et al., Biol Psychiatry 2005 : Thus, at 10 mg/kg ( i.p. ), SPD induced Fos expression in the medial prefrontal cortex ( mPFC ), nucleus accumbens (NAc), and lateral septal nucleus ( LSN ) without significantly affecting the dorsolateral striatum (DLSt) ... At higher doses ( 20-40 mg/kg ), SPD also increased Fos expression in the DLSt ... Within the NAc, SPD also induced more Fos expression in the shell than in the core ... In all subcortical areas examined, the Fos expression induced by SPD was mimicked by the D2 antagonist sulpiride and reversed by the D2 agonist quinpirole, suggesting that the effect is due to blockade of D2-like receptors by SPD ... These results suggest that, in the mPFC, SPD may induce Fos expression through a non-DA mechanism
Guo et al., Life Sci 1998 : In this work SPD induced Fos immunoreactivity was examined ... In the normal rats, Fos was induced in the striatum by SPD ( 1-20 mg/kg, i.p. ) dose-dependently ... Therefore, we concluded that the Fos expression induced by SPD in intact and denervated striatum was mediated via D2 and D1 receptor respectively, supporting the previous standpoint that SPD possesses the dual action, i.e antagonist to D2 and agonist to D1 receptors