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FOXP3 — IL4

Text-mined interactions from Literome

Mantel et al., PLoS Biol 2007 : We demonstrated that interleukin 4 (IL-4) present at the time of T cell priming inhibits FOXP3
Dardalhon et al., Nat Immunol 2008 : Here we show that IL-4 blocked the generation of TGF-beta induced Foxp3 ( + ) T ( reg ) cells and instead induced a population of T helper cells that produced IL-9 and IL-10
Chaput et al., Gut 2009 (Adenocarcinoma...) : Finally, interleukin 6 and TGF beta 1 synergistically induced the generation of CD8 ( + ) CD25 ( + ) Foxp3 ( + ) T cells ex vivo
Hadjur et al., Immunol Lett 2009 : Here we use a co-culture system to demonstrate that IL4 provided by Th2 cells in vitro is sufficient to block Foxp3 induction in naive CD4 T cells
Dewals et al., Eur J Immunol 2010 (Schistosomiasis mansoni) : This was due to IL-4 mediated inhibition of CD4 ( + ) Foxp3 ( + ) Treg conversion, demonstrated in adoptively transferred Rag2 ( - ) ( / ) ( - ) mice ... Together, these results demonstrate that IL-4 signalling in T cells inhibits Foxp3 ( + ) Treg in vivo and promotes CD4 ( + ) CD25 ( - ) CD103 ( + ) Foxp3 ( - ) cells that control S. mansoni egg induced inflammation via IL-10
Beal et al., Nat Immunol 2012 : Abortive Foxp3 expression was caused by production of interleukin 4 (IL-4) by Ndfip1 ( -/- ) cells
Elliott et al., Ann N Y Acad Sci 2012 (Immune System Diseases...) : Helminth exposure tends to inhibit IFN-? and IL-17 production, promote IL-4 , IL-10, and TGF-ß release, induce CD4 ( + ) T cell Foxp3 expression, and generate regulatory macrophages, dendritic cells, and B cells
Knosp et al., J Immunol 2013 : Collectively, these results suggest that SOCS2 may prevent IL-4 induced Foxp3 ( + ) iTreg instability