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NFKB1 — POMC

Text-mined interactions from Literome

Karalis et al., J Biol Chem 2004 : To further investigate the role of NF-kappaB on the CRH induced pituitary POMC gene activation, AtT20 cells were transiently transfected with a POMC-luciferase construct mutated at an NF-kappaB binding site
Liu et al., Mol Pharmacol 2006 (Lung Neoplasms...) : Exogenous supply of alpha-MSH inhibited NFkappaB activities, whereas application of the alpha-MSH antagonist growth hormone releasing peptide-6 ( GHRP-6 ) abolished the POMC induced inhibition of NFkappaB activities and melanoma growth in mice
Seo et al., Neuroscience 2008 (Pain) : In conclusion, POMC mRNA expression in the arcuate nucleus of the hypothalamus was increased by inflammatory pain stimuli, in which pERK1/2, pCaMK-IIalpha and NFkappaB may play an important role in the expression of the hypothalamic POMC gene and beta-endorphin expression
Jang et al., J Biol Chem 2010 (Anorexia) : In vitro, NF-kappaB activation directly stimulated the transcriptional activity of pro-opiomelanocortin (POMC) , a precursor of anorexigenic melanocortin, and mediated the stimulatory effects of LPS, Tat, and pro-inflammatory cytokines on POMC transcription, implying the involvement of NF-kappaB in controlling feeding behavior