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CYBB — NFKB1
Text-mined interactions from Literome
Anrather et al., J Biol Chem 2006
:
NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of
gp91phox ... We also found that
gp91(phox) transcription is
dependent on
NF-kappaB and we identified two potential cis acting elements in the murine gp91(phox) promoter that control NF-kappaB dependent regulation
Ueno et al., J Surg Res 2006
:
Lack of
Cybb had little effect on
NF-kappa B and STAT3 binding, and no effect in TNFa and interleukin-6 production after PH. Cybb KO mice had normal liver structure and similar levels of hepatocyte DNA replication as those of wild type mice
Gauss et al., J Leukoc Biol 2007
:
Pharmacological inhibitors of
NF-kappaB activation
blocked TNF-alpha induced up-regulation of NCF1, NCF2, and
CYBB message, which correlated with a reduction in expression of the corresponding oxidase proteins and decreased O2*- production
Luengo-Blanco et al., Blood 2008
(Ectodermal Dysplasia...) :
This work investigated the functional
role of
nuclear factor-kappaB (NF-kappaB) in respiratory burst activity and in expression of the human phagocyte nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase genes
CYBB , CYBA, NCF1, and NCF2 ... These studies show that
NF-kappaB is
necessary for
CYBB and NCF1 gene expression and activation of the phagocyte NADPH oxidase in this model system