Gene interactions and pathways from curated databases and text-mining

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CYBB — NFKB1

Text-mined interactions from Literome

Anrather et al., J Biol Chem 2006 : NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox ... We also found that gp91(phox) transcription is dependent on NF-kappaB and we identified two potential cis acting elements in the murine gp91(phox) promoter that control NF-kappaB dependent regulation
Ueno et al., J Surg Res 2006 : Lack of Cybb had little effect on NF-kappa B and STAT3 binding, and no effect in TNFa and interleukin-6 production after PH. Cybb KO mice had normal liver structure and similar levels of hepatocyte DNA replication as those of wild type mice
Gauss et al., J Leukoc Biol 2007 : Pharmacological inhibitors of NF-kappaB activation blocked TNF-alpha induced up-regulation of NCF1, NCF2, and CYBB message, which correlated with a reduction in expression of the corresponding oxidase proteins and decreased O2*- production
Luengo-Blanco et al., Blood 2008 (Ectodermal Dysplasia...) : This work investigated the functional role of nuclear factor-kappaB (NF-kappaB) in respiratory burst activity and in expression of the human phagocyte nicotinamide adenine dinucleotide phosphate ( NADPH ) oxidase genes CYBB , CYBA, NCF1, and NCF2 ... These studies show that NF-kappaB is necessary for CYBB and NCF1 gene expression and activation of the phagocyte NADPH oxidase in this model system